摘要

Objectives: The main objective is to demonstrate the clinical benefits of transdermal delivery of nano-structured calcium hydroxyapatite (nano-CaHA) through non-insulated radiofrequency microneedling (RFMN), emphasizing its potential for integration into combination therapies in clinical practice aimed at promoting skin rejuvenation. Introduction: In skin rejuvenation therapy, combined techniques are widely used to maximize the clinical results by complementary mechanisms. While chemical peel agents, such as retinoic acid (RA), promote cell turnover, RFMN induces neocollagenesis via thermal stimulation and controlled microdamage. RFMN also provides a direct route for transdermal drugs. Nano-CaHA has emerged as a promising agent for transdermal application due to its biocompatibility, bioactivity, and ability to stimulate dermal regeneration through fibroblasts activation, neocollagenesis and inflammation modulation. Materials / method: 34 adults with aging signs underwent monthly RFMN sessions followed by transdermal nano-CaHA for 2 months. After anesthesia, the skin was treated with RFMN in continuous mode with 24-karat gold 49-microneedle handpieces, by parameters adapted to region and tissue thickness. Nano-CaHA was applied immediately, followed by 5% retinoic acid to seal the skin, kept for 3 hours at home. Homecare included gentle cleansing, thermal water, repair cream plus low-potency corticosteroid twice daily for 3 days, and daily physical sunscreen during all treatment. The evolution was registered by Quantificare. Results: The association between Nano-CaHA and RFMN, sealed by retinoic acid 5% showed an important clinical improvement of aging signs, including wrinkles, texture, radiance, homogeneity, and elasticity after only 2 sessions. Patients were also reported the self-perception of global skin quality improvement with high satisfaction. No unexpected adverse effects were observed due to these associations. Conclusion: The experience herewith reported suggests that combined therapy, including the transdermal application of nano-CaHA via RFMN, accelerates skin rejuvenation with minimal downtime and few adverse events, leading to high patient satisfaction. Further studies with larger samples are needed to confirm safety and efficacy.