摘要

Objectives: To understand the complementary mechanisms of PDLLA and oral collagen supplementation in skin regeneration. To explore practical aspects of protocol design, patient selection, and clinical integration. To evaluate the potential benefits of this combined approach for short- and long-term outcomes. To identify why biostimulating treatments sometimes fail and how adjunctive therapies can improve success rates. To discuss the future role of synergistic therapies in advancing aesthetic medicine. Introduction: Poly-D,L-lactic acid (PDLLA) is an emerging biostimulatory filler that stimulates neocollagenesis for long-term skin quality improvements. Oral collagen supplementation, recognised as a supportive, non-invasive adjunct, may enhance regeneration and outcomes. This protocol combines PDLLA with targeted supplementation, while also addressing why biostimulation can fail—such as poor collagen metabolism, oxidative stress, or lifestyle factors—to optimise conditions for treatment success. Materials / method: Scientific rationale: PDLLA-induced collagenesis and how oral collagen supports systemic metabolism. Protocol design: sequencing, dosage, and integration into practice. Clinical outcomes: early gains in elasticity, hydration, and satisfaction. Safety: counselling and adherence strategies. Why biostimulation fails: systemic, lifestyle, and clinical limits, plus ways to address them. Future perspectives: combined protocols may define a new standard in regenerative aesthetic medicine. Results: In-clinic research and results to be presented by Dr Barbara Kubicka Conclusion: By presenting this innovative dual strategy, Dr Barbara Kubicka will provide delegates with an evidence-informed, clinically applicable framework for enhancing skin quality through synergistic biostimulation.