摘要

Objectives: 1. Assess skin aspect and the correlation with the skin microbiome in adults living in big cities, 2. Analyze the effects of a topical lotion containing a prebiotic associated with trace elements. Introduction: Skin of people living in urban areas are subjected to pollution, particulate matter, xenobiotics (as biphenyls polychlorate, dioxin, etc). Their impact on the skin tone, texture and on skin microbiome could be important. Materials / method: In a multicentric, open study were included adults living in polluted cities with no skin pathology of he facial skin. Were analyzed clinically the cosmetic features of the skin of the face (skin tone, texture), associated with spectrophotometry, were also performed e-swabs for the metagenomic taxonomy analysis of the facial skin microbiome. During 3 weeks was applied BID a lotion containing prebiotic inulin and trace-elements copper and zinc. The same clinical, spectrophotometry and microbiome’s metagenomic assessments were made at week 3 and compared to baseline. Results: Were included 80 women living in different big cities from Europe and SE Asia. The uneven skin tone and skin surface texture were improved at W3 compared to baseline, spectrophotometry showed a decrease of parameter L* (red) . Skin microbiome was improved at W3 compared to baseline: increase of saprophyte bacteria Cutibacterium and S.epidermidis, decrease of conditioned pathogenic Staphylococci, the other bacteria of the microbiome remained unchanged. Conclusion: In a series of 80 women living in polluted areas, a topical lotion formulated with the prebiotic inulin and with trace-elements improved significantly skin aspect and microbiome at week 3 compared to baseline.