摘要

Objectives: To understand the role of incretin hormones, particularly Glucagon Like Peptide-1 (GLP-1) and Glucose Insulinotropic Polypeptide (GIP) in health and disease. To understand the effects of incretin based medications, including GLP-1 RA and dual agonists (GIP/GLP-1 RA) in Type 2 diabetes and obesity To understand the potential non glycaemic benefits on other conditions such as obstructive sleep apnoea, heart failure with preserved ejection fraction, peripheral vascular disease and liver disease To understand the the potential contraindications and side effects of these medications Introduction: Incretin hormones such as GLP-1 and GIP have a significant role in modulating insulin and glucagon secretion in response to food intake, Analogues of these “gut hormones” including GLP- RA, dual agonists (GIP/ GLP-1 RA) as well as DPP 4 inhibitors have been used in Type 2 diabetes, and increasingly, the injectable medications have become part of the pharmacotherapeutic options for the management of obesity. These medications were initially injected twice, the once a day, and now once a week with research exploring different dosing frequencies in the future for newer medications Materials / method: The presentation will provide a review of the available information concerinng incretins and future research Results: This presentation will summarise how and why incretin hormones are important in health and disease, particularly in Type 2 diabetes and obesity, as well as expanding potential therapeutic roles in cardiovascular disease, sleep apnoea and heart failure with preserved ejection fraction. The use of these agents, however should be accompanied by a detailed discussion of their contraindications and potential side effects. Conclusion: Incretin hormones and incretin based therapies have been the focus of research for many years. Therapies now have become an important part of the armamentarium used in Type 2 diabetes, obesity and other conditions. Effects on mental health, alcohol consumption and other non -glycaemic effects are forthcoming, necessitating a detailed discussion about the indications, contraindications and monitoring of people prescrtibed these medications.