摘要

Objectives: This review aims to evaluate the efficacy of exosomes and PDRN in oxidative stress-induced skin aging. It explores how both agents mitigate ROS damage, promote collagen production, and enhance tissue regeneration, highlighting their synergistic role in preventing and reversing aging signs. Introduction: Oxidative stress plays a central role in skin aging by damaging DNA, lipids, and proteins. This leads to collagen degradation, mitochondrial dysfunction, cellular senescence, and inflammation. Understanding this process, along with the body’s enzymatic and non-enzymatic antioxidant defenses, is essential to optimize protective and therapeutic strategies. Materials / method: A literature review of clinical and experimental studies was conducted to evaluate exosomes and PDRN effects on skin aging. Parameters assessed included collagen synthesis, inflammation, and matrix repair. Lifestyle elements—diet, supplementation, and environmental exposure—were also considered for their synergistic impact. Results: Exosomes modulate inflammation and activate fibroblasts, while PDRN promotes angiogenesis and tissue repair. Combined, they improve elasticity, reduce wrinkles, and reverse oxidative damage. Supporting endogenous antioxidant systems through lifestyle and supplementation further enhances regenerative outcomes. Conclusion: Understanding oxidative damage and boosting the body’s antioxidant defense—through lifestyle, diet, and supplementation—enhances the efficacy of regenerative therapies. When combined, exosomes and PDRN represent a powerful strategy against oxidative stress-induced aging, offering safe, effective, and integrative skin rejuvenation.