摘要

Objectives: To evaluate the use of Seffiller as a rejuvenation strategy based on adipose-derived cells, focusing on the preservation of skin quality, early modulation of inflammatory aging mechanisms, and promotion of skin longevity through preventive cellular interventions. Introduction: Skin aging involves chronic low grade inflammation, extracellular matrix degradation, and reduced regenerative capacity. Rejuvenation proposes early interventions to preserve tissue homeostasis. Seffiller, obtained through mechanical processing of autologous adipose tissue, preserves a viable and bioactive cellular fraction, representing a promising regenerative approach for skin longevity. Materials / method: Clinical protocols using Seffiller were evaluated, with intradermal and superficial subcutaneous application, either alone or combined with bioestimulatory injectables and energy-based devices. Clinical assessment include skin quality, texture, elasticity, radiance, and subclinical inflammatory signs, with longitudinal follow-up, in compliance with ethical and regulatory principles. Results: Seffiller based protocols demonstrated progressive improvement in overall skin quality with increased elasticity, improved texture and radiance, and reduction of subclinical inflammatory signs. greater stability of results over time and enhanced skin response to combination treatments were observed, suggesting increased cutaneous resilience. Conclusion: Seffiller represents an effective cellular strategy for skin prejuvenation and longevity. By acting early on the cutaneous microenvironment, it supports tissue homeostasis and expands the preventive paradigm, shifting the focus from corrective treatment to the continuous construction of skin health and quality.