摘要

Objectives: The aetiology of androgenetic alopecia involves both genetics and adrogens, as verified by the testosterone in hair follicles. Unless a therapeutic intervention halts this process, hair loss will become progressively more severe, manifesting psycho-social consequences such as a higher incidence of anxiety, depression, and compromised self-esteem. Current treatments include lasers, RF, Dutasteride, a dual type I and type II 5α-reductase inhibitor, and finasteride, which is not as potent in inhibiting II enzyme action. Resonance and energy technologies are now widening the alopecia perspective. Introduction: Male baldness affects up to half of the male population by middle age, and almost all men by old age. Especially in younger men, this heritable form of hair loss can have significant psycho-social consequences. Overall, pharmacological approaches for the prevention of hair loss and to hair regrowth are in their infancy. This is underpinned by a paucity in understanding the underlying molecular mechanisms that contribute to the pathogenesis of baldness. Resonance and energy technologies are now widening the perspective of alopecia treatments. Materials / method: We looked at the molecular mechanisms underlying male baldness to understand the efficacy of different procedures including, lases, RF and pharmacological treatments. Then we used the The Hamilton–Norwood baldness scale, that ranges from Type I, no baldness to type III and IV of noticeable baldness, to evaluate male pattern baldness in four single study designs that compared radiofrequency alone, laser alone, radiofrequency plus pharmacotherapy and laser plus pharmacotherapy, and RET resonance energy transfer alone. Results: The four male subjects were approximately the same age with similar lifestyles Results were evaluated immediately for side effects and after one month for hair growth. Side effects were most pronounced with both radiofrequency procedures, with and without pharmacotherapy. No side effects were observed with the RET procedures Conclusion: Immediate evaluation of the RET technology revealed no adverse reactions or side effects After one month RET appeared to have more hair growth both subjectively in terms of patient satisfaction, and objectively as measured by the Hamilton-Norwood baldness scale. Observed immediately after treatment, the two radiofrequency conditions had the most side effects when compared to the other treatments. Laser plus pharmacotherapy was superior to laser-no pharmacotherapy and the two radiofrequency conditions (radiofrequency alone and radiofrequency plus pharmacotherapy)