摘要

Objectives: This scoping review aims to revisit and reposition the potential of non-ablative fractional lasers within a fluence-dependent continuum of tissue modulation based on histological and molecular evidence. Introduction: Near-infrared non-ablative fractional lasers (NAFL) are long established for skin rejuvenation and scar treatment procedures and have attracted interest for their expanding therapeutic potential. Materials / method: A literature search was conducted across PubMed (MEDLINE), the Cochrane Library, and Google Scholar on February 5th, 2025, with no publication date restrictions and limited to English-language articles. The search strategy combined free-text keywords and MeSH terms related to 1540-1550 nm NAFL and skin remodeling. Studies were eligible if they investigated laser-skin interactions, at either histological or molecular level, assessed through biopsy, immunohistochemistry or gene-expression analysis. Results: A total of 27 studies were included, comprising 17 investigations of histological laser-tissue interactions and 10 studies assessing molecular responses. Conclusion: By integrating evidence from histological and molecular studies, this review repositions NAFL within a fluence-dependent continuum of tissue modulation, ranging from pure non-ablative interactions to a progressively barrier-disruptive, semi-ablative, treatment modality. This framework holds potential for broadening NAFL clinical scope, particularly for applications in laser-assisted drug delivery and skin cancer prevention.