将激光技术与再生注射剂相结合

目标: Melasma 介绍: Melasma is a chronic, relapsing pigmentary disorder whose pathogenesis involves three levels: hyperactive epidermal melanocytes, dermal extracellular matrix damage with a weakened basement membrane, and a vascular and inflammatory component. Treatment directed at pigment alone produces only temporary improvement, with relapse rates reported at 60-70%. We present two cases treated with a combined protocol addressing all three levels within a single visit. 材料 / 方法: In both cases the following steps were performed sequentially within a single visit: microneedling radiofrequency for dermal remodelling and neocollagenesis; fractional 1927 nm thulium laser with a penetration depth of 200-300 microns targeting epidermal pigment; and immediate topical application of a biphasic complex of plant-derived exosomes with peptides and amino acids through the laser-created microchannels. The topical product was used strictly in accordance with its registration as a topicalIn both preparation 结果: Both cases showed reduced pigment intensity and improved skin tone and texture. Case 1 additionally showed reduction of the vascular component together with improved skin density. No post-inflammatory hyperpigmentation was observed in either case, including in skin type IV. Photographic documentation was obtained under standardised lighting, angle and camera settings, including ultraviolet imaging. 总结: The combination of energy-based treatment with immediate topical delivery of a regenerative complex appears to be a promising strategy for the control of melasma, including in darker skin types, and warrants confirmation in controlled studies. Conflict of interest: to be declared in the dedicated COI field of the submission form. No product, device, company or brand names appear in the title or body; only generic terms and technical characteristics are used.