Elena PARSAGASHVILI 医师
皮肤科医师
Insensitivity to botulinum toxin type A therapy in aesthetic practice: causes and solutions
目标: Discussing botulinum toxin type A insensitivity in aesthetic practice and understanding its causes helps avoid unsatisfactory clinical results.
介绍: The generally accepted differential diagnosis of primary and secondary immunoresistance is supplemented here by a discussion of possible exogenous and endogenous causes of variable response to therapy in the same patient.
材料 / 方法: A retrospective comparative analysis of two groups of patients based on their medical histories was conducted. The first group received the drug reconstituted ex tempore, and the second received the drug after a week of storage.
结果: An analysis of patients' medical records showed a reduction in the duration of the effect when using reconstituted BoNT-A in violation of the storage periods recommended in the instructions.
总结: Large-scale clinical studies are needed to evaluate the duration of therapeutic effect of botulinum toxin type A after storage for the recommended shelf life, with particular attention to reconstitution.
