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Objectives: We will review the newest medical therapies for androgenetic alopecia (AGA): oral minoxidil, mesotherapy with dutasteride, oral spironolactone and oral bicalutamide. We will present a proposal of therapeutic algorithms for male and female AGA.

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Objectives: Treatment with three JAK inhibitors, ruxolitinib, baricitinib and tofacitinib, led to hair regrowth in alopecia areata patients. Here we review the current landscape for JAK inhibitors in alopecia aerate.

Introduction: JAK inhibitors are small molecules that are capable of blocking T-cell-mediated inflammation. They have been shown to be beneficial in several inflammatory conditions, such as rheumatoid arthritis, psoriasis and psoriatic arthritis.

Materials / method: JAK inhibitors have gained widespread popularity for the treatment of moderate-to-severe alopecia areata patients.

Results: Treatment with JAK inhibitors can be efficacious but can lead to adverse events, with infections being the most worrisome. Furthermore, the durability of JAK inhibitors for alopecia areata is still unknown. Clinical trials with topical and systemic JAK inhibitors for alopecia areata are ongoing, and hopefully will provide us with better understanding of the safety and efficacy of these medications.

Conclusion: If treatments with JAK inhibitors prove to be effective and safe, they might become the first FDA-approved treatment for alopecia areata.

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利益冲突声明

您有否接受任何资金来支持研究这个主题？
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您是否接受过关于这项研究的任何酬金或其他报酬？
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你是否和任何与您的研究所涉及的药物，材料或工具有密切联系的实体存在财务关系？
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你是否拥有或者您已经为您此研究中的工具，药物或材料申请任何专利？
否

这项工作没有任何直接或间接的资金支持。由作者自己承担责任。