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Objectives: 1. To understand that adipose stem cell exosome (ASCE) can be a paradigm shift in regenerative aesthetics & therapeutics
2. To find that ASCE can attenuate severe inflammation and promote skin barrier reconstruction in atopic dermatitis model
3. To know that ASCE can improve dupilumab facial redness (DFR) and acne scar
4. To know that ASCE can make scalp rejuvenation and hair loss prevention

Introduction: Exosomes, nano-sized extracellular vesicles, are the most important mediator for intercellular communication. For last years, the dual function of skin regeneration and anti-inflammation of ASCE has been well known from a number of research. These days, ASCEs are being developed as next generation regenerative therapeutics and aesthetics as well. From our various studies, it has been shown that ASCE can be an innovative biomaterial as regenerative therapeutics as well as regenerative aesthetics for treatment of atopic dermatitis, acne scar, facial redness, & scalp rejuvenation/hair loss.

Materials / method: Human adipose mesenchymal stem cell-derived exosomes (ASCE) and a specific formulation including ASCE were applied or treated for a variety of in vitro, in vivo, & clinical studies.

Results: 1. ASCE could reduce or modulate over-reactive inflammation in skin in atopic dermatitis model. The AD score was significantly improved and major proinflammatory cytokines including IL-4, IL-13, TLSP, & others were down-regulated.
2. ASCE could promote the de novo synthesis of ceramide and dihydroceramide, key lipid molecules in skin barrier formation, which led to the significant improvement of atopic dermatitis model.
3. When compared to PRP, ASCE and a specific formulation could successfully improve the results in terms of rejuvenating the scalp and reducing hair loss.

Conclusion: ASCE may serve as next generation technology with competitive advantages over conventional regenerative aesthetics or therapeutics, in terms of regeneration and anti-inflammation.

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请注明名称（个人，公司，学会等等）: EXOCOBIO INC

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请注明名称（个人，公司，学会等等）: EXOCOBIO INC

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请注明日期: Patented
和审阅情况: July 2018

这项工作的完成感谢以下机构的支持： ExoCoBio Inc

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Objectives: Objectives:
Demonstrate how the “Scanning Motion” technology is faster, less painful, and more effective than other laser technologies.

Introduction: Over the years, laser technology for permanent hair removal has evolved, not only seeking to reduce the number of sessions, that is, to achieve more effectiveness in the patient, but also to be much more comfortable for the doctor and with a very low margin of risk.

Materials / method: Objectives:
Demonstrate how the “Scanning Motion” technology is faster, less painful, and more effective than other laser technologies.

Introduction:
Over the years, laser technology for permanent hair removal has evolved, not only seeking to reduce the number of sessions, that is, to achieve more effectiveness in the patient

Materials:
Laser 755nm and 808 nm

Results: smooth non-irritated skin (mild erythema)

Conclusion: The combination of different technologies for permanent hair removal is ideal for achieving faster results but with safer and more effective techniques. And if we add to this, motion scanning makes the treatment more comfortable in small and large areas without the need to use gel or anesthesia, thanks to All this is thanks to the contact cooling sistem and additional air.

Motion scanning Technology is a revolutionary way that scans small areas from 10 mm x 15 mm or large areas of 50 mm by 15 mm in approximately 0.5 seconds to 1.5 seconds at very high density with Power of 2400 / cm2, allowi

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