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Objectives: Explain the evolution of regenerative medicine to exosomes.

Introduction: Regenerative medicine uses or manipulates the body's own repair and regeneration capacity as anti-aging therapies. Early on and still important are mesenchymal stem cells, but as we understand more about the way cells communicate, exosomes become important tools in aesthetic and anti-aging therapies.

Materials / method: To present a personal evolution in regenerative medicine from the earliest adipose derived stem cells to the development of hydrasomes, the authors will present the present landscape and clinical implementation of exosomes.

Results: Nearly 300 patients have undergone independent dermatologic studies as well as split face studies showing superiority of hybrasomes over retinol and Augustine Bader cosmetics. Clinical validation at the authors' center confirm marked improvement in skin aging and appearance using a 2 month course of topical hybrasome creams.

Conclusion: The cosmetic and cosmeceutical fields are undergoing a historic change from synthesized compounds to using regenerative medical techniques to improve aesthetics while reversing aging in our cells and facial tissues. To avoid the "wild west" phenomenom of every exosome product is the same, scientific validation is absolutely necessary to determine both safety and efficacy prior to using them on the market.

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Objectives: At the conclusion of this learning activity, attendees should be able to:
1) Understand extracellular vesicles (EV), how they are used and made
2) Describe some of the data in exosome science
3) Be able to critically review the data and decide if/why one should employ exosomes in their clinical practice

Introduction: Exosomes, a form of extracellular vesicles are exploding in clinical usage, but the data regarding their usefulness, contents and clinical outcomes remains scant.

Materials / method: Use available evidence to boil down the science and bring attendees up to speed on what is out there/being studied in the field.

Results: Extracellular vesicles/exosomes are derived from a number of sources and produced in a number of different ways. This lecture will cover some of the science behind the sources, providing attendees with essential knowledge by which they can critically review available data and make decisions for their practice.

Conclusion: Describe the science behind EV and exosomes and consider whether to deploy in practice.

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