Objectives: 1. Discuss the rationale for anatomic and regenerative facial fat grafting
2. Demonstrate the technique
3. Present 19 month prospective outcome data
Introduction: A standardized technique for facial fat grafting, Injectable Tissue Replacement and Regeneration (ITR2), was developed to address both anatomic volume losses in superficial and deep fat compartments as well as skin aging, incorporating newer regenerative approaches.
Materials / method: Twenty-nine female patients with a mean age of 52.9 years and mean BMI of 22.5 kg/ m2 were analyzed for mid-facial volume changes after autologous fat transfer with ITR2. Estimates of volume change over the course of 19 months were evaluated using the Vectra XT 3D Imaging System to calculate volume differences between a predefined, 3-dimensional mid-facial zone measured preoperatively and serially after fat grafting with novel approach using varying fat parcel sizes and using an overlaid postoperative 3D image.
Results: Patient data was analyzed collectively as well as separately by age (< and> 55 years). Collective analysis revealed a trend of initial volume loss within the first 1-7 months followed by an increase in facial volume within 8–19-month range, averaging 56.6% postoperative gain within the first 1-3 months and ending at an average of 52.3% gain in mid-facial volume by 14-19 months. A similar trend was observed for patients <55 years of age, but to a greater extent. Patients above 55 years of age demonstrated a gradual volume loss to around 30% improvement at 19 months after treatment.
Conclusion: Preliminary evidence shows a dynamic change in facial volume, with an initial decrease in facial volume followed by a rebound effect that demonstrated improvement of facial volume regardless of patient weight change or amount of fat injected 19 months after treatment. Volume improvement occurred to a greater extent in patients under 55 years old, whereas in patients older than 55 volume gradually decreased. To our knowledge, this study represents the first time that progressive improvement in facial volume has been shown 19 months after treatment.
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