Objectives: To evaluate the efficacy of a multifaceted treatment regimen combining with exosomes (Rose Stem Cells-Exosomes, RSCEs) with fractional lasers, RF microneedling, and subcision techniques in the management of acne scars.

Introduction: Acne scarring is a challenging condition that affects both the physical appearance and psychological well-being of patients. Traditional treatments have offered limited success, prompting the exploration of innovative approaches.

Materials / method: The study employed a combination of exosomes application, fractional laser therapy, RF microneedling, and subcision in a cohort of patients with varying degrees of acne scarring. Treatment efficacy was evaluated through comparative before-and-after analyses, considering scar depth, skin texture, and patient satisfaction.

Results: Significant improvements were observed in scar appearance, skin texture, and overall patient satisfaction. The combined treatment regimen was found to be more effective than traditional methods, with minimal side effects and reduced recovery time. The findings suggest that the synergistic effects of exosomes and minimally invasive procedures can significantly enhance the outcomes of acne scar treatments. This approach not only accelerates the healing process but also addresses the aesthetic and functional concerns associated with acne scarring.

Conclusion: The study demonstrates the potential of combining exosomes with advanced dermatological techniques to improve acne scar treatment outcomes. Further research is recommended to optimize treatment protocols and evaluate long-term effects.

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Objectives: The needle-less syringe is revolutionary. It is very fast and has functions that cannot be done with manual injection. In particular, it can produce groundbreaking and good results in the treatment of acne scars. I would like to do a biopsy and show photos of the tissue reaction and discuss it together.

Objectives: This work aims to assess the impact of sequential multimodal laser therapy on acne scar geometrics and texture.

Introduction: Scarring is one of the most prevalent long-term complications of acne vulgaris and has cosmetic, psychological and social burdens. Contemporary management programs integrate multiple modalities to best address the multiple factors underlying their development and persistence.

Materials / method: This is a prospective open-label trial of sixteen (n=16) patients. Adult patients with Fitzpatrick skin type II-IV and presenting facial acne scars (combination of box, rolling and icepick scars) were recruited and underwent three combination fractional ablative (CO2) and nonablative (1570 nm) laser treatment sessions at two-month intervals. Scar microtopography was assessed at baseline and 6 months after the last treatment.

Results: Patient cohort included 9 men and 7 women, average age of 29.3±7.9 years. Mean pretreatment scar volume was 5.7±5.2 mm3 and mean affected area was 165.6±134.0 mm2. Overall scarring intensity was moderate in 9 and severe in 7 patients. Six months after treatment sessions, scarring intensity improved in all patients, with all severe cases graded as moderate and all moderate cases graded as mild. Mean scar volume was 3.1±3.0 mm3 and the mean affected area was 94.0±80.1 mm2, translating to 47.0±7.9% and 43.2±8.6% reductions from baseline, respectively. Patients were highly satisfied.

Conclusion: Multimodal CO2 and 1570-nm laser treatment improved the surface profilometry of patients with atrophic facial acne scars. Customization of both treatment intervals and laser settings to cosmetic regions, scar profiles and skin phototypes may further enhance treatment outcomes and expand its applicability to additional skin deformities.

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