Objectives: To investigate the effects of full-face intradermal compound collagen injection on skin properties.
Introduction: Collagen, a key component of the extracellular matrix (ECM), plays a critical role in maintaining skin firmness and elasticity. With aging and exposure to factors such as ultraviolet light and chemical stressors, collagen undergoes reduced synthesis, increased degradation, and alterations in subtype ratios, leading to facial aging and wrinkle formation. In recent years, collagen has become a widely used agent in aesthetic injectable treatments due to its ability to regulate extracellular matrix mechanisms and ameliorate vascular inflammatory responses.
Materials / method: Nine eligible subjects meeting inclusion/exclusion criteria underwent a single full-face compound collagen negative-pressure microneedle injection (5 mL, 12.5 mg) at a depth of 1.0–1.2 mm. Skin parameters were evaluated at D0 (baseline), immediately post-treatment, D7, and D28 using the following measurements: (VISIA®, Canfield);(MPA580®, Courage + Khazaka); (Ultrascan UC22®, Courage + Khazaka).
Results: All nine subjects completed the 28-day follow-up without complications. Statistically significant differences (P < 0.05) were observed in the percentage changes at D28 for hydration, radiance, elasticity parameters R2 (%), F4/(mm·s), and epidermal and dermal thickness compared to baseline.
Conclusion: Intradermal collagen injection is a safe and effective method to improve skin properties in subjects.
利益冲突声明
您有否接受任何资金来支持研究这个主题?
否
您是否接受过关于这项研究的任何酬金或其他报酬?
否
你是否和任何与您的研究所涉及的药物,材料或工具有密切联系的实体存在财务关系?
否
你是否拥有或者您已经为您此研究中的工具,药物或材料申请任何专利?
否
这项工作没有任何直接或间接的资金支持。由作者自己承担责任。