Objectives: This study aims to evaluate the effectiveness and safety of labia majora rejuvenation with a new method by bi-filler {plasma jell) plus polycaprolactone-based filler fallowed PRP.
Introduction: Female external genitalia lose elasticity and volume with age, and start to lose fatty tissue, get wrinkled. This is why many patients seek on some kind of labia majora augmentation and rejuvenation. Currently, lipofilling and hyaluronic acid (HA) based injections are two most popular methods for this purpose. The first is invasive and need operation room and the second one is expensive and both of them absorb rapidly.
Materials / method: This is a prospective single group pilot study that was performed on 20 female patients desiring labia majora rejuvenation. All patients were complained about hypotrophy and hyperpigmentation of the labia majora. After taking written informed consent, they received two sessions of plasma gel plus polycaprolactone (PCL) based filler injections in subcutaneous layer and fallowed by PRP in intradermal layer at the same time in each labia majora at 3-month interval. They were assessed clinically before treatment sessions and at the end of follow-up period (6th month).
Results: All patients showed immediate significant clinical improvement after injection that maintained till the end of follow-up period. This finding was confirmed by significant reduction in the mean values of Wrinkle Severity Rating Scale (WSRS) and significant improvement of skin homogeneity and texture with slightly augmentation and bulking with high Visual Analog Patient Satisfaction Scale (VAS) score. In general, the reported side effects were minimal and transient.
Conclusion: Autologous platelet poor plasma gel injection seems to be a cost-effective, safe, well-tolerated, and minimally invasive technique producing significant aesthetic correction of labia majora wrinkles and augmentation.
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