Objectives: - Understand the role and mechanism of action of PBSerum recombinant enzymes (collagenase, lipase and lyase) and HMWHA in the management of fibrosis-related pathologies.
- Establish the possible causes of fibrosis development and scar tissue formation: diagnostic approach and treatment strategy based on PBSerum recombinant enzymes and HMWHA.

Introduction: The use of recombinant enzymes along with HMWHA in the treatment of diverse skin problems is generating an increasingly significant interest thanks to their differential advantages over other active principles. While HMWA has proven efficacy in the prevention and treatment of fibrosis, enzymes are very selective molecules that catalyze metabolic reactions, being specific for a substrate on which they act without damaging adjacent structures. This specificity reduces the possibility of having any complication or adverse effect and it is responsible for their high security and efficacy level.

Materials / method: - PBSerum recombinant enzymes (collagenase, lipase, lyase)

- High Molecular Weight Hyaluronic Acid

Results: HMWHA decreases the rate of the fibrosis in affected tissues, playing a key role in its prevention and treatment.

Recombinant enzymes have proven efficacy in the treatment of diverse skin pathologies: fat accumulation, cellulite, flaccidity, scars, fibrosis… The clinical practice has revealed that they degrade specifically the substrates that mainly cause them (collagenase removes atrophic collagen fibers that lead to flaccidity and fibrosis, lipase degrades TG inside the adipocyte reducing fat accumulation and lyase acts in synergy with the other enzymes as a vehicle to help their expansion)

Conclusion: The combination of PBSerum recombinant enzymes with HMWHA have shown very favorable and encouraging results that may change the approach in the way certain skin pathologies have been treated so far.

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利益冲突声明

您有否接受任何资金来支持研究这个主题？
否

您是否接受过关于这项研究的任何酬金或其他报酬？
否

你是否和任何与您的研究所涉及的药物，材料或工具有密切联系的实体存在财务关系？
否

你是否拥有或者您已经为您此研究中的工具，药物或材料申请任何专利？
否

这项工作没有任何直接或间接的资金支持。由作者自己承担责任。