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Objectives: Genital rejuvenation, are medical procedures that is born of the concern of these experts for the well-being of women and their sexual satisfaction
Vulvovaginal laxity the term, encompasses laxity of both the vaginal introitus and labia majora
Vaginal relaxation syndrome causes different symptoms such as lack of sexual pleasure or urine loss.
Orgasmic dysfunction, reduced friction during sex due to ‘looseness’, and other aspects of laxity-related changes are perceived to negatively impact the sexual experience in a variety of ways

Introduction: Vulvovaginal rejuvenation with devices binding laser or radiofrequency (RF) energy (among others), but all these devices has a problem for make his therapeutic action. The atrophy of the connective tissue because the genitourinary syndrome of menopause, or the Vagina Relaxation Syndrome don’t allow find a good therapeutic answer.

Materials / method: It is important prepare the tissue before the use of these devices to prepare the connective tissue and fat tissue to find a good beneficial result.
Our first option nowadays is the use of Carboxytherapy.
Carboxytherapy consists of the therapeutic use of carbon dioxide (CO2) in its gaseous state, by subcuta¬neous injection.
At the vascular level, CO2 increases vascular tone and produces active microcirculatory vasodilatation. CO2-induced vasodilatation.In addition, this promotes Bohr’s effect, that increase the PO2 in the tissue.

Results: CO2 promotes this mechanism, resulting in a higher tissue oxygenation and neoangiogenesis.
Also, produce a stimulation over the fibroblast with increase the collagen in the connective tissue. All these pharmacodynamics action of the CO2 justified his biostimulation action and the preparation of the tissue for another treatment or not. Sometimes, only the used of CO2 find a good therapeutic result

Conclusion: Today we have a gel combination that claim produce CO2. The effects of a transdermal gel that is claimed to produce CO2 are very encouraging with regard to stimulation of the cutaneous microcirculation.
Different short studies with FSFI, VHI, clinic studies, photography evolution and biopsies show the benefits of the CO2 Vaginal Gel for the treatment of the symptoms and signs of the vulvo vaginal atrophy. Also I published (Pubmed) an study where we can see the improve of microcirculation in the connective tissue.

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请注明名称（个人，公司，学会等等）: i did a scientific reseacrh was published (Pubmed) and I received economy support

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这项工作的完成感谢以下机构的支持： lumisque LLC

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Objectives: To evaluate the effectiveness of the use of carboxitherapy, mesotherapy and mesobotox for the management of several conditions related to the aging process: sagging skin, hyperpigmentation, and symptoms related to the lack of estrogens.

Keywords: Carboxitherapy, mesotherapy, mesotox.

Introduction: Treatment of tropism of the genital areas, such as with vulvar sagging skin or hyperpigmentation and vaginal dryness, though use of nonablative carboxytherapy or mesotherapy, as well as mesotox.

Materials / method: Patients, with vulvar sagging skin or hyperpigmentation and vaginal dryness, underwent a treatment that consisted of several applications of vulvar and vaginal carboxytherapy or several sessions of mesotherapy as well as the use of mesotox technique.
The procedure was painless, and there were no complications. Pictures of before-and-after, as well as the evaluation of patient’s satisfaction with the Visual Analogue Scale (VAS), were done in the follow-up: immediately, and at one and at three months.

Results: A significant objective aesthetic improvement of the patient conditions was observed in all patients, post-treatment, in all follow up. Subjectively, VAS showed that all treated patients were satisfied with the final outcome achieved.

Conclusion: Our results show that the use of carboxitherapy, mesotherapy, and mesotox. effectively improves the aesthetic appearance of the external genitalia and symptoms related to the lack of estrogens, giving the vulva a younger appearance and achieving optimal patient satisfaction.

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