Katrine KARMISHOLT 医师
皮肤科医师
丹麦
其他作者
: Karmisholt1 Katrine, Haerskjold 1 Ann, Karlsmark1 Tonny, Waibel2 Jill, Paasch3 U, Haedersdal1 Merete 1Department of Dermatology, Venereology and Wound Healing, Bispebjerg University Hospital, Copenhagen, Denmark 2Miami Dermatology and Laser Institute, Mia
Objectives: The aim of this study is to systematically review and evaluate clinical evidence for early laser intervention introduced in inflammation, proliferation or remodeling phases of wound healing with first treatment performed <3 months after wounding.
Introduction: Surgical procedures will inevitable leave a scar. For many patients their surgical scar may pose itching, pain, restriction of movement and disfiguration. Within recent years the ability of laser treatment to affect wound healing and subsequently minimize scar formation has been investigated.
Materials / method: We searched PubMed using relevant key words. Titles, abstracts and articles were sorted according to inclusion and exclusion criteria. Methodological quality was evaluated according to Cochrane Collaborations risk-of-bias assessment guideline by two independent authors.
Results: Twenty-five articles met the inclusion criteria. In general, laser treated wounds and scars showed benefit from laser intervention, though not always reaching significance. Significant scar improvements were found in: 3 of 4 studies using laser treatment in inflammation phase, in 6 of 16 studies with laser initiated in the proliferation phase and in 2 of 5 studies in the remodeling phase. Methodological quality included high risk-of- bias in terms of randomization and allocation concealment, but low risk-of-bias with regard to blinding of outcome assessment and lost to follow-up.
Conclusion: Laser intervention to reduce scar formation. Studies with longer follow-up and higher quality are needed.
利益冲突声明
您有否接受任何资金来支持研究这个主题?
否
您是否接受过关于这项研究的任何酬金或其他报酬?
否
你是否和任何与您的研究所涉及的药物,材料或工具有密切联系的实体存在财务关系?
否
你是否拥有或者您已经为您此研究中的工具,药物或材料申请任何专利?
否
这项工作没有任何直接或间接的资金支持。由作者自己承担责任。