Objectives: At today there are no studies that have investigated in skin biopsies whether multiple pollutants can affect skin physiology
Introduction: Since the skin is one of the targets of the harmful effects of environmental insults, several studies have investigated the effects of outdoor stressors on cutaneous tissue. In fact, ozone (O3), particulate matter (PM, arises from diesel exhaust), and ultraviolet (UV) light have all been shown to induce skin damage through disruption of redox homeostasis, resulting in oxinflammation.
Materials / method: In this study, we investigated whether O3, PM, and UV, which are the most common environmental skin insults, acted synergistically in inducing skin damage, and whether we could prevent this effect through topical application of a specific topical mixture, containing 15% vitamin C, 1% vitamin E, and 0.5% ferulic acid. Human skin explants obtained from three different subjects were sequentially exposed to 200 mJ UV light, 0.25 ppm O3 for 2 hrs, and 30 min of diesel engine exhaust (DEE), alone or in combination for 4 days (time point D1 and D4).
Results: We observed a clear additive effect of O3 and DEE in combination with UV in increasing levels of several oxidative (4HNE, HO-1) and inflammatory (COX2, NF-κB) markers and loss of barrier-associated proteins, such as filaggrin and involucrin. Furthermore, daily topical pre-treatment with the mixture prevented upregulation of the inflammatory and oxidative markers and the loss of both involucrin and filaggrin.
Conclusion: In conclusion, this study is the first to investigate the combined effects of three of the most noxious outdoor stressors on human skin and suggests that daily topical application is a useful approach to prevent pollution-induced skin damage
利益冲突声明
您有否接受任何资金来支持研究这个主题？
是
请注明名称（个人，公司，学会等等）: Skinceuticals
您是否接受过关于这项研究的任何酬金或其他报酬？
否
你是否和任何与您的研究所涉及的药物，材料或工具有密切联系的实体存在财务关系？
否
你是否拥有或者您已经为您此研究中的工具，药物或材料申请任何专利？
否
这项工作的完成感谢以下机构的支持： Skinceuticals
