Objectives: We will present the impact of risk factors associated with urban life on the skin aging process. with urban life and dermatologists' role in reducing the effects of these factors.

Introduction: A sophisticated and dynamic organ, skin serves as a barrier between the internal environment and the world outside, yet has numerous functions that go far beyond that role, such as homeostatic regulation, prevention of percutaneous loss of fluid, electrolytes, and proteins, temperature maintenance, sensory perception, and immune surveillance.

Because of its visibility, skin health and skin appearance can influence self-esteem, mental status, social interactions, and overall quality of life. The face is the primary source of information in social perception.

Materials / method: Aging is a complex process in all human societies reflecting biological, environmental, and genetic influences. It is multidimensional, comprising physical, psychological, and social change influenced by cultural and societal standards.

The skin represents the interface between external and internal aggressions; hence it undergoes aging under the influence of both internal (intrinsic) factors and external (extrinsic) agents. These two aging processes are clinically and biologically different.

Results: In our opinion, the urban lifestyle is best characterized by lack of time and overcrowded cities, which is associated with the acceleration of skin aging. Our lack of time and prolonged exposure to these harmful factors are the most critical factors in skin aging (sun, smoking, sugar, stress, sleep, skincare, and pollution).

Conclusion: Modern urban living can be summarized by unhealthy eating habits, sedentary life, sleep disturbances, and chronic exposure to pollution, stress, UV, and smoking. We, therefore, propose “urban skin aging” as a new concept on aging.
All efforts should be directed towards maintaining the functional and anatomical integrity of the skin, and the main challenge is to go beyond maintaining an appearance.

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Objectives: Understanding the importance of the connection between Microbiota, Microbiome and Skin Diseases

Introduction: Recent scientific investigation have shown that the human body is host to around 100 trillion microbes. They outnumber the human cells in the body 10 to 1.
Microbial Cells and their genetic material are important for immunity, inflammation and behaviour.
The microbiome of normal human skin was found to have a high diversity and high interpersonal variation. Microbiota compositions of diseased lesional skin (in atopic dermatitis and psoriasis) showed distinct differences compared with healthy skin.

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这项工作的完成感谢以下机构的支持：

Objectives: The attendees will receive in few minutes all the necessary data about the composition and physiology of the healthy skin barrier and the changes that result in (or result from) some common and important dermatoses

Introduction: Skin barrier was classically defined as composed of bricks (keratinocytes) and mortar (inter-cellular lipids). This description still holds a strong ground. Recent advances in research technology expanded our knowledge and many interesting details were added in the last two decades.

Materials / method: Reviewing the literature and correlating the details together are necessary to understand and appreciate the value of the intact healthy skin barrier and how its components integrate to achieve the ultimate function. The skin barrier helps to keep optimum moisture, temperature and shape of the integument. It also provides a necessary balanced medium for the essential microbiome and it protects against invading pathogens and obnoxious irritants and allergens.

Results: Changes accompanying atopy, psoriasis, eczema, aging and fungal infections are important to understand and manage.

Conclusion: Understanding the structure and physiology of the skin barrier is important to help keep the skin healthy, functioning and beautiful and crucial in managing diseases in which this barrier is disturbed.

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请注明名称（个人，公司，学会等等）: European grant 222230 ristomed FP7

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请注明日期: granted
和审阅情况: 2007

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