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Objectives: ABSTRACT
Objectives: The aim of this study was to evaluate the safety and efficacy of the use of Fat graft enhanced with Stromal Vascular fraction cells (FG-SVFs) in face rejuvenation for esthetic improvement and also for scars.

Introduction: The use of FG-SVFs and also FG not enhanced have been described for many years, without a specific focus on comparison between FG-SVFs and FG in face rejuvenation and outcomes of scars and related soft tissue defects.

Materials / method: Methods: 33 female patients affected by face’s soft-tissue defects with loss of volume, study group (SG), were treated with FG-SVFs, comparing results with a control group (CG) (n = 30) treated with fat graft not enhanced (FG). Clinical evaluation, a photographic assessment, magnetic resonance imaging (MRI),
and ultrasound (US) were performed. Post-operative follow-up was performed at 1, 3, 7, 12, 24, 48, weeks, and then annually.

Results: Results: Study group patients (treated with FG-SVFs) showed 61% maintenance of the contour restoring and of volume after 3 years compared with the CG treated with FG (not enhanced), who showed 31% maintenance.
60.7% (n = 20) of SG patients, presented an increase of 6.6 mm in the soft tissue volume after 36 months, which was reported in only 33,3% (n = 10) of the CG. Volumetric persistence in the SG was higher than that in the CG (p <. 0001 vs.
CG). MRI and US moreover confirmed the absence of important side effects, as fat necrosis, and cytosteatonecrotic areas.

Conclusion: Conclusions: The use of FG-SVFs was safe and effective in this series of a case treated.

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