Objectives: To assess the current evidence base for injectables in gender-affirming care and identify unmet needs.

Introduction: Although visibility of LGBTQIA+ individuals continues to rise, including 1.6% of adults (over 4 million) in the USA who are transgender and/or nonbinary, they remain an understudied and underserved population who experience significant physical and mental health disparities, Gender dysphoria is particularly associated with suboptimal healthcare, social exclusion, lower quality of life, and higher incidence of co-morbidities as well as higher mortality in every age group. Gender-affirming care has been demonstrated to improve quality of life and psychological well-being.

Materials / method: As demand for gender-affirming care becomes more visible, there is growing recognition of the role of minimally invasive procedures including injectables. To date, peer-reviewed publications have focused on anecdotal techniques and results, as may happen in any emerging field.

This work presents a needs assessment for injectables in gender-affirming care.

Results: Treatments with injectable fillers and neuromodulators represent unique and important components of gender-affirming care with the benefits of being minimally invasive, and favorable safety profiles when performed appropriately. Identified and analyzed unmet needs will be presented.

Conclusion: The rationale of supporting medically appropriate, evidence-based practice that reflects cultural awareness, knowledge, sensitivity and competence enables this work to be extrapolated to other minimally invasive aesthetic procedures.

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请注明名称（个人，公司，学会等等）: This presentation includes data from an independent initiative supported by Galderma for which the author serves as the Chair. The presentation itself is independent and under the author's own responsibility.

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Objectives: 1. To review priorities of transgender individuals in gender affirmation therapy
2. To review the management of adverse effects of hormonal therapy
3. To review feature of sexual dimorphism and injectable strategies to aid in gender affirmation

Introduction: Gender dysphoria contributes to decreased quality of life and health outcomes in transgender and gender non-binary individuals. Transition therapy is multidisciplinary and may improve quality of life by aligning phenotype with gender identity.

Materials / method: Literature review

Results: During transition therapy, transgender women prioritize the face while transgender men prioritize the chest. Adverse effects of hormonal therapy include acne, androgenetic alopecia and melasma, which may be managed conventionally. It is paramount to elicit transgender or intersex patient preferences during injectable facial reshaping, as their idea of beauty may not align with ideals of sexual dimorphism. Laser hair reduction, botulinum toxin and injectable hyaluronic acid/biostimulants may improve gender dysphoria by aligning phenotype with gender identity.

Conclusion: Dermatology may play an important role during gender affirmation therapy by treating adverse effects of hormonal therapy and by patient-centered use of injectables. Dermatologic needs unique to transgender patients is a knowledge gap in dermatology and warrants further research and inclusion in residency training.

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