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Objectives: 1. Explain the importance of anti-aging and longevity in the aesthetic practice
2. Discuss the potential impact on aesthetic care and outcomes
3. Present a simple means of incorporating longevity and wellness into your practice

Introduction: With the tremendous increase in our understanding of the human genome and the conditions that are often either present at birth or modified with lifestyle, aesthetic medicine, dermatology and plastic surgery are well positioned to be leaders in this emerging field. Herein, we present a simple means of biologic age testing, AI insight into the pace of aging, relative telomere length and intrinsic and extrinsic biologic age, online consultation with a genetic engineer and creation of personalized supplements, lifestyle changes and biohacking to optimize longevity and wellness.

Materials / method: Patients undergo a series of blood tests, a fingerstick, a photographic image of their face and upload their medical history. Within a few weeks, a consultation with a genetic engineer is scheduled. During the consultation, your test results will be reviewed and personalized recommendations based on your particular epigenetics as well as your blood work and history will be made.

Results: Intrinsic and extrinsic biologic age, biomarkers of inflammation, telomere length, pace of aging, dietary response and diabetes risk among other information is given to the patients. Patients begin on their personalized regimen and then 6-12 months later, the studies and consultation are repeated.

Conclusion: In the new world of aesthetic medicine, wellness and longevity will have a prominent role. As caregivers, those of us who practice aesthetic medicine and surgery are in a perfect position to help our patients not only with their youthful appearances, but to make even more meaningful changes in their overall health.

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请注明名称（个人，公司，学会等等）: Mage Group

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Objectives: Circadian rhythms are physical, mental, and behavioral changes that follow a 24-hour cycle. These processes respond during daylight and nighttime. The circadian system is composed of peripheral circadian oscillators in many other cells, including the skin. In this talk, I dive into the role that circadian rhythm has on the skin and how you can best support it with specialized skincare.

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Objectives: Microbiota, Cytokines, Treatment, Inflammatory, Skin diseases, Immunology

Introduction: The human gut microbiota has received considerable interest in the recent years and our knowledge of the inhabitant species and their potential applications is increased particularly after the development of metagenomic studies. Gut microbiota is highly diverse and harboring trillions of microorganisms in human digestive system.

Materials / method: The P.N.E.I. (Psycho-Neuro-Endocrine-Immunology) approach is represented by the interdisciplinary concept of bidirectional cross-talk between the psycho-neuro-endocrine and immune systems, which can influence the immune response. The well-known Gut-Brain Axis and the Gut-Skin Axis can be merged in a bigger network- the Gut-Brain-Skin Axis, with complex regulation by cytokines, neuro-peptides, neuro-hormones and another messenger (signalling) molecules and maybe the most important modulator of the Gut-Brain-Skin Axis/ the gut microbiota.

Results: The role of gut bacterial homeostasis is very important, and the homeostatic imbalance of the immune response may be a relevant etiologic/pathophysiologic factor for extra-intestinal and intestinal inflammatory, allergic and autoimmune diseases. The Low Dose Cytokines Medicine (LDM) is an innovative therapeutic approach. It is based on the most advanced knowledge in molecular biology and low dose pharmacology with the primary outcome.

Conclusion: In conclusion presently microbiota represents the "main organ" which needs proper investigation and treatment for each and every successful anti aging procedures and/or programs.

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