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Objectives: The purpose of this study was to examine whether the anti-aging potential of Retinaldehyde could be enhanced by combining it with natural retinol analogs without compromising its favorable skin irritation profile.

Introduction: Although retinoids remain the treatment of choice for photoaging, their beneficial effects are gradual and progressive and are compromised by unfavorable irritation potentials. Considering this, we hypothesized that the anti-photoaging potential of the retinoid acid precursor Retinaldehyde (RAL) could be enhanced by combining it with two plant-derived retinoid analogs, Bakuchiol (BAK) and Vigna aconitifolia extract (VAE), which have themselves been shown to deliver retinoid-like anti-aging benefits without side-effects.

Materials / method: Gene expression profiling of full thickness reconstructed skin was first used to examine the impact of BAK or VAE in combination with RAL on skin biology in vitro. Next, the irritative potential of this combination, and its capacity to reverse key signs of photoaging in an ex vivo model, was assessed. Finally, a proof-of-concept, open label clinical study was performed to evaluate the anti-aging capacity and skin compatibility of a cosmetic formulation containing this complex in combination with other well characterized anti-aging ingredients.

Results: In vitro, RAL in combination with BAK or VAE potentiated the effect of RAL on keratinocyte differentiation and skin barrier function without affecting its skin irritation profile. This combination also reversed UV-induced damage in an ex vivo model of photoaging. In vivo it led to the rapid reversal of clinical signs of age and photodamage, with statistically significant improvements to skin firmness (+5.6%), skin elasticity (+13.9%), wrinkle count (-43.2%), and skin tone homogeneity (+7.0%) observed within 28 days of use. Notably, the number of wrinkles was reduced in 100% of subjects.

Conclusion: Using a translational approach to cosmetic development we have shown how the anti-aging effects of RAL can be enhanced by combining it with the natural retinol analogues BAK and VAE, without affecting the preferential safety profile of RAL. Reductions in clinical signs of aging and photodamage are observed within one month of once daily use, making it a highly effective and well-tolerated alternative treatment for photoaging.

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请注明名称（个人，公司，学会等等）: ISDIN

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Objectives: We showcase a series of cases featuring distinctive and successful combinations of in-office procedures as chemical peels and lasers, integrating cosmeceuticals with the triple-combination of Retinal, Bakuquiol and topical melatonin.

Introduction: Cosmeceuticals represent topical formulations featuring higher concentrations of active ingredients compared to mainstream cosmetics. These formulations incorporate a diverse array of active components, synergistically working together to deliver outstanding outcomes within a relatively brief timeframe.
Retinal, boasts regenerative and anti-aging properties. Its efficacy is further enhanced when combined with retinoid-like elements such as bakuquiol and a topical antioxidant like melatonin. Remarkable results can be achieved when used in conjunction with in-office procedures.

Materials / method: We present the clinical insights and potential combinations involving a cosmeceutical merging Retinal with Bakuqiol and melatonin, in conjunction with in-office procedures.

Results: The clinical photographs depicting patients undergoing laser and peeling procedures, coupled with the concurrent use of this cosmeceutical at home, reveal a noticeable enhancement in skin quality. This improvement is evident in the reduction of imperfections, pigmentation issues, and other irregularities associated with photoaging.

Conclusion: These approaches contribute to effective anti-aging treatments, yielding visible results in a short span.

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请注明名称（个人，公司，学会等等）: ISDIN SL

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请注明名称（个人，公司，学会等等）: Medical advisor of ISDIN SL

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这项工作的完成感谢以下机构的支持： ISDIN SL