Objectives: Hair therapy moves billions of dollars annually, many health professionals do not know how to enter this market. In the class I will demonstrate the conventional treatments and their combinations for the treatment of telogen effluvium and androgenetic alopecia, as well as the new ultrasound technology that diagnoses protein loss and how to restore the hair shaft by combining it with vegan serums , most of the time caused by excess of treatments made in hairdressing salons and in people's own homes

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Objectives: To evaluate scalp sensation in AGA vs non-AGA males

Introduction: AGA is characterized by miniaturization of hair. We hypothesized that the areas with AGA had reduction of scalp sensation.

Materials / method: We tested sensation of the scalp with monofilaments, 2-point discrimination tests, thermal sensation.

Results: Areas with AGA had reduced scalp sensation.

Conclusion: AGA is associated with scalp neuropathy.

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Objectives: Objectives -To explore cetirizine’s potential as a PGD2 pathway inhibitor and its role in reducing hair follicle miniaturization in AGA.

Introduction: Cetirizine has demonstrated inhibitory effects on prostaglandin D2 synthesis, a molecule implicated in the pathogenesis of hair follicle miniaturization in AGA. PGD2 acts as a potent inhibitor of hair growth by inducing catagen, the regression phase of the hair cycle, and reducing the anagen phase duration. Cetirizine's ability to block PGD2 receptor pathways offers a novel mechanism for combating AGA progression.

Materials / method: Men between 18 to 60 years of age with AGA, Norwood - Hamilton grade III vertex to V were enrolled. Men on minoxidil, finasteride, or other anti-androgenic medications within the past 6 months were excluded. The patients were given 1ml of 1% topical cetirizine in 30% propylene glycol and 30% butylene glycol daily for 16 weeks. Patients were also given non-medicated shampoo. No other topical or systemic therapy was given. Two efficacy parameters assessed were: hair count and 7-point evaluation Global photography images were captured on an Indigenous stereotactic device.

Results: Ten men were recruited. An increase in the hair count in 9/9 subjects post 16 weeks of therapy( one drop out). The mean hair count at week 0 was 139.56 (SE of the mean of 13.92) while the mean hair count at 16 weeks was 163.44 (SE of mean of 15.52)(P< 0.05). Global photography evaluation showed one patient had +2 change, two had +1 change, and six had no change. None of the patents reported any adverse effects.

Conclusion: Cetirizine's ability to block PGD2 receptor pathways offers a novel mechanism for combating AGA progression. All nine patients showed increased hair count on trichoscopy compared to baseline, however standardized photographs revealed improvement in only three. This discrepancy arises because hair grows at approximately one cm per month, so after four months, approximately four cm length of hair may not visibly enhance density in photographs. While current evidence supports its efficacy and safety, larger, randomized controlled trials are necessary

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Objectives: The objective of this presentation is to establish evidence-based guidelines for selecting exosomes that maximize safety and efficacy in skin and hair regeneration therapies. The session will explore critical variables such as cell source, cultivation methods, extraction timing, purification processes, and preservation techniques, providing a comprehensive framework for clinicians and researchers to identify the most suitable exosomes for clinical use.

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Objectives: We will discuss the development of exosome therapy, the importance of immune tolerance induced by HLA-G expression, and the signals that influence hair growth promotion.

Conclusion: In hair loss treatment, synthetic exosomes that possess immune tolerance abilities through HLA-G expression and are rich in signals that promote hair growth will play a crucial role.

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