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Peelings, mesotherapy & needling - Contributed talks

会议室： Room 151 - Level 1
日期： 2025年 2月 1日星期六从 16:00 至 17:30
组织形式： 投稿演讲 > 基于对提交的演示文稿摘要的审核，学术委员会通过的投稿演讲。

主席

Oge ONWUDIWE 医师

皮肤科医师

美国

Priti SHENAI 医师

皮肤科医师

印度

本场演讲内容

小时	讲者	演讲标题	讲稿摘要	数字
16:00	Georgios KRAVVAS 医师	Successful treatment of keratosis pilaris with a novel chemical peel of trichloroacetic acid 20%, kojic acid, and mandelic acid	查看	140749
16:10	Maria Florencia VERA MORANDINI 医师	Menopausal skin: Combined approach for flaccidity and photoaging	查看	140750
16:20	Jennifer LINDER 医师	Leveraging topical acids to control cellular senescence	查看	140751
16:30	Mauricio Orlando MENDEZ ESPANA 医师	Phenol peeling for rejuvenation	查看	140752
16:40	Joseph Andrei BONGALO 医师	Effective delivery of polydeoxyribonucleotides for facial rejuvenation	查看	140753
16:50	Soha GHANIAN 医师	Exploring the effects of phenol and croton oil delivered by tattooing	查看	140755
17:00	Yaser ALGAIDI 医师	Tranexamic acid as a therapeutic option for melasma management: Meta-analysis and systematic review of randomized controlled trials	查看	140756
17:10		Q&A		140757

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Georgios KRAVVAS 医师

皮肤科医师

英国

其他作者 :

Successful treatment of keratosis pilaris with a novel chemical peel of trichloroacetic acid 20%, kojic acid, and mandelic acid

Objectives: Share our experience of treating keratosis pilaris (KP) with a novel chemical peel, and describe the cosmetic outcomes, side effects, and patient experience.

Introduction: KP is a common, hard-to-treat skin condition that leads to a distinctive rough texture of the affected areas.

Chemical peels have previously been used in the management of KP with inconsistent, often unsatisfactory, results.

More recently developed chemical peels composed of multiple acids attempt to leverage the synergistic effects of different active ingredients in order to target skin concerns more effectively. This multifaceted approach can result in improved cosmetic outcomes, but also in a reduced number of treatments and downtime.

Materials / method: We assessed the efficacy and safety of treatment with a chemical peel of trichloroacetic acid (TCA) 20%, kojic acid, and mandelic acid in the management of adult patients with keratosis pilaris.

A total of six fortnightly treatments (2ml for 6-8 minutes) were applied to the affected areas over a period of three months.

Medical photographs were obtained pre and post treatment and used for comparison.

Pre and post-treatment outcomes were determined using investigator global assessment (IGA), global improvement score (GIS), and patient satisfaction scores.

Results: Four patients were treated using the above protocol.

All four patients achieved significant improvement in lesion count, lesion size, and overall texture of the treated skin compared to their baseline. Furthermore, moderate improvement was achieved in the reduction of erythema. Patient satisfaction scores showed a significant improvement compared to the baseline.

Other than mild, transient irritation, no other side effects were reported or observed.

These results were found to be consistent across all four patients without significant interpatient variations in outcomes.

Conclusion: Chemical peels containing TCA 20%, kojic acid, and mandelic acid were able to successfully and consistently control the roughness associated with KP, but were less effective in reducing erythema.

The lack of side effects allows for immediate resumption of social activities by patients without the need for a downtime.

Satisfaction scores suggest that patients put greater weight in improvement of KP-associated roughness compared to erythema.

Further studies are required in order to assess long-term outcomes and to establish protocols for maintenance therapy.

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Maria Florencia VERA MORANDINI 医师

皮肤科医师

西班牙

其他作者 : Maria Florencia Vera Morandini

Menopausal skin: Combined approach for flaccidity and photoaging

Objectives: To assess the safety and efficacy of a synergistic protocol for treating flaccidity, which is
based on combining different products in order to to treat flaccidity in perimenopausal
and postmenopausal women.

Introduction: Facial ageing is a continuous and multifactorial process caused by different molecular
and cell changes. The decrease in oestrogen levels during menopause plays a key role
as it is linked to a decrease in transforming growth factor beta (TGF-β),1 the main
activator of extracellular matrix proteins (collagen, elastin, HA, reticulin). mesohyal®
redenx contains palmitoyl tripeptide-5, which activates TGF-β2 , helping to restore the
endogenous cutaneous mechanism in perimenopausal and postmenopausal women.

Materials / method: A clinical study was carried out between July and December 2023 involving 13
perimenopausal and postmenopausal patients divided into two groups based on the
degree of ageing. The protocol aimed skin renewal with peels, cell biostimulation with
mesotherapy, volume replacement with filler and homecare treatment to promote and
maintain long-term results. It consisted of 1 session with 20/25 mg/ml cross-linked HA,
3 mesotherapy sessions (15 mg/ml free HA, palmitoyl tripeptide-5, acetyl tetrapeptide-9
and DMAE) and 3 peel sessions (18% lactic acid, 18% glycolic acid, 2% retin@l, 1%
bakuchiol) for m

Results: The clinical results of the two study groups demonstrate noticeable skin rejuvenation,
with reduced pigmentation and improved skin quality. In addition, the replacement of
the facial support structures provides structure and firmness to the skin, thereby
correcting facial sagging. Ex vivo data demonstrated an increase in TGF-β on kin
explants treated with biomimetic peptides and analysed using immunofluorescence
microscopy.

Conclusion: This therapeutic strategy for treating flaccidity is a comprehensive approach that
improves the signs of flaccidity by acting on different skin planes and cellular targets.
Peels are recommended to stimulate skin regeneration, mesotherapy to administer
active ingredients for cellular biostimulation and cross-linked HA fillers to restore facial
volume. Ex vivo studies have shown that peptides act at cellular and tissue levels,
improving fibroblast function and stimulating the synthesis of ECM proteins, resulting in
improved skin quality when tested clinically.

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Jennifer LINDER 医师

皮肤科医师

美国

其他作者 : Ivana Veljkovic, PhD

Leveraging topical acids to control cellular senescence

Objectives: Describe the potential senolytic effects of topical acids in chemical peels, identify topical agents effective in reducing cellular senescence and improving mitochondrial health, and Identify AHA formulations that effectively counteract senescence with limited inflammation as outlined in recent research and data.

Introduction: Senescence is a natural part of the cell cycle influenced by both genetic and epigenetic factors. Understanding cellular senescence and its role in the underlying mechanisms of aging is crucial for all aspects of medicine. Studies have shown that topical alpha hydroxy acids (AHA) may reduce senescence cells and senescence-associated secretory phenotype (SASP) and improve the overall mitochondrial health of the skin cells. Unfortunately, the inflammation associated with traditional chemical peels' high percentages and low pH may counteract these benefits.

Materials / method: A search of PUBMED databases was performed to identify relevant literature published within the last five years, focusing on the potential senescence-controlling activity of topical alpha hydroxy acids (AHA). Additionally, we reviewed data highlighting findings for ideal parameters such as pH in peel efficacy, patient tolerance, and overall outcomes.

Results: Even superficial chemical peels that utilize AHA have traditionally caused significant surface inflammation. While studies show a potential reduction in senescence and improvement in mitochondrial function, they must be used in appropriate formulations to achieve this benefit. Newer science indicates a potential link between regular acute inflammation--much like that associated with traditional chemical peels--and cellular senescence.

Conclusion: Inflammation causes or exacerbates all cosmetic skin concerns. In addition, inflammation can lead to premature senescence and cellular damage. While inflammation was once our only option for creating change in the skin, science now offers new ways to work with the skin rather than against it, leveraging non-inflammatory, no-downtime AHA formulations.

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Mauricio Orlando MENDEZ ESPANA 医师

医师

墨西哥

其他作者 :

Phenol peeling for rejuvenation

Objectives: The objective of the study is to demonstrate that performing a phenol peel correctly with the characteristics that it requires will result in very natural, soft and beautiful results.

Specific objective: to inform doctors when a peel is considered and that we run risks; or what is a reversal protocol to avoid complications.

Introduction: A phenol peel is a deep peel that is sometimes recommended for the treatment of severe wrinkles (from fine lines to deep folds), sun damage, uneven skin tone and texture and can be used in the treatment of precancerous skin conditions. Phenol is particularly helpful in minimizing the vertical lines that often form around the mouth as a result of aging. Deep peels take longer to perform and will leave a healing crust on the skin that should be covered with a protective ointment and limited to sun exposure. There is a burning sensation, but it is somewhat relieved because the solution also acts

Materials / method: As methods, different types of population 1; population to perform phenol well called chemical blepharoplasty; 2; elderly patients who underwent it for rejuvenation purposes; 3; Patients with acne sequelae

I made the formulations with different percentages; but always using phenol, novisol and crutton oil

Results: The results seemed magnificent. We have patients with a very good degree of skin retraction, in addition to that; also in one of our patients who had a very delimited basal cell cancer, it was completely erased.
The results of the application of phenol in the orbit for rejuvenation were very good; excellent results
and we also noticed the lightening of the patients; likewise, reducing all the photodamage from the sun; lentigines, and elemental lesions.

Conclusion: Conclusions:
Today, phenol peeling is still very controversial due to the hemodynamic and cardiological manifestations that the patient may present; therefore, I suggest a surgical evaluation to be able to perform it with an anesthesiologist and obtain optimal results
The reality is that our results were very good and I will be explaining my detailed way of applying it

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Joseph Andrei BONGALO 医师

医师

菲律宾

其他作者 :

Effective delivery of polydeoxyribonucleotides for facial rejuvenation

Objectives: 1. Define skin rejuvenation and skin boosters
2. Understand the mechanism of action of Polydeoxyribonucleotides for facial rejuvenation
3. Identify different methods of transdermal delivery of Polydeoxiribonucleotides

Introduction: Polydeoxyribonucleotide or PDRN is a DNA-derived drug consisting of a mixture of double-stranded deoxyribonucleotides with a chain length of 80–2,200 base pairs with a molecular weight ranging from 50-1500 kDa. PDRN is extracted and purified from the sperm cells of Oncorhynchus mykiss, commonly known as salmon trout, which provide high-quality DNA without immunological side effects. Initially intended for tissue regeneration for chronic non healing wounds, its regenerative properties paved its way to be utilized in the field of medical aesthetics and dermatology for skin rejuvenation.

Materials / method: The use of various microneedling instruments, followed by topical application of PDRN or a PDRN cocktail combined with growth factors, peptides, vitamins and non-cross linked hyaluronic acid are performed by clinicians for better skin penetration. Another method is the use of a multi suction injector which aims to combine microneedling with mesotherapy principles.

Results: The device allows advanced solution delivery with a 9-pin multi needle and vacuum function to minimize the leakage of solution, minimize pain and shorten treatment time.

Conclusion: Hence, the delivery of PDRN into the skin using a multi suction injector is more precise and the potential leakage is prevented.

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Soha GHANIAN 医师

皮肤科医师

美国

其他作者 : Carlos Gustavo Wambier, MD, PhD

Exploring the effects of phenol and croton oil delivered by tattooing

Objectives: Assess microscopic depth of injury and neocollagen production with use of deep chemical peels (Hetter's very heavy formula containing 1.6% croton oil in 35% phenol and pure croton oil) via drug-tattooing technique versus topical application alone using cotton-tipped applicator

Introduction: Deep chemical peels can consist of a mixture of phenol, croton oil, water, and emulsifying agent (Septisol [SEP]). Baker-Gordon’s (2.1% croton oil/49.3% phenol) and Hetter’s standardized formulas (1.6% croton oil/35% phenol) are some examples of deep chemical peels. Depth of injury of deep chemical peels is often variable and difficult to assess, especially when applying the chemical agents using a simple cotton tipped applicator.

Materials / method: Using a porcine in vivo model, dermal delivery of pure croton oil and Hetter’s formula was performed with drug-tattooing technique using Cheyenne Hawk Pen 23-Magnum SE set at 120 Hz with 1.5 mm needle depth. Punch biopsies were obtained (hematoxylin and eosin) 24 hours later to assess microscopic depth of injury based on necrosis/neutrophilic band (measured in micrometers and evaluated via black India tattoo ink) and 21 days later to assess neocollagen production (Herovici collagen stain). Three test sites were used for Hetter’s formula, pure croton oil, and black India tattoo ink (control).

Results: Deeper dermal injury was measured with the pure croton oil tattooing compared to tattooing of Hetter’s formula. Topical application of pure croton oil did not cause evident dermal injury.

Conclusion: Drug-tattooing can be a promising method of drug delivery (particularly with non-phenol containing chemical peels, like pure croton oil) and is associated with deeper dermal penetration and neocollagenesis. Future studies using human subjects are needed to assess depth of penetration of chemical peel formulas for a variety of clinical indications, including scarring, dyspigmentation, sun damage, and wrinkles. More studies also need to be done with more dilute croton oil solution to further assess depth of injury and neocollagenesis with varying concentrations of chemical formulas.

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Yaser ALGAIDI 医师

医师

爱尔兰

其他作者 : Retaj Calacattawi 1, Mohammed Alshahrani 2, Maryam Aleid 3, Fatimah Aleid 3, Khalid Basamih 4, Ghada Alsugair 5, Raghad Alqahtani 6, Noor AlKhabbaz 3, Yaser Algaidi 7, Latifa Alrakayan 3, Abdulaziz Almohanna 8, Afnan Madkhali 9, Shaima Aljohani 10, Naif A

Tranexamic acid as a therapeutic option for melasma management: Meta-analysis and systematic review of randomized controlled trials

Objectives: To assess the efficacy of tranexamic acid (TXA) in treating melasma and evaluate its associated adverse effects compared to other melasma treatments.

Introduction: Melasma is a challenging condition to treat. Tranexamic acid (TXA) has emerged as a promising therapy, but its effectiveness and safety compared to other treatments need comprehensive evaluation.

Materials / method: A systematic review and meta-analysis were conducted on 22 RCTs (n=1280 patients) following PROSPERO and PRISMA guidelines. Databases searched included PubMed, Scopus, Cochrane, and Embase. Inclusion criteria focused on full-text English RCTs with clear outcome measures on TXA in melasma. Data were analyzed using RevMan software, with heterogeneity assessed using I² statistics and forest plots.

Results: TXA was administered orally, topically, or via injection. Significant reductions were observed in MASI (mean difference: -4.32) and mMASI scores. Oral TXA was most effective, followed by injections and topical treatments. Adverse effects included gastrointestinal issues and skin irritation.

Conclusion: TXA is effective in reducing melasma severity, but further research is needed to optimize administration methods and address treatment heterogeneity.

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2025 英卡思巴黎国际年会 大会日程

Peelings, mesotherapy & needling - Contributed talks

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