Objectives: An evidence-based overview of the main cosmeceuticals distributed in the market, relevant to their safety and efficacy is sought via this presentation.

Introduction: Cosmeceuticals is a growing class of agents not recognized or regulated by the US Food and Drug Administration (FDA). Nevertheless they have captured the attention of clinical and basic researchers and have been adopted by many consumers interested in anti-aging and skin rejuvenation.

Materials / method: The MEDLINE and Cochrane Library databases were searched for clinical studies on the major classes of cosmeceuticals: growth factors, peptides, stem cells, anti-oxidants, and pigment/erythema-reducing agents and the results were evaluated in respect to the clinical and scientific level of evidence.

Results: Despite the paucity of rigorous clinical studies, several cosmeceutical agents have shown promising results as treatment options for photoaging and other skin indications. The latest formulations containing growth factors, peptides and stem cells, are novel and promising advances, but still in early stages of exploration to promote their claims as therapeutic anti-aging agents. Most thorough clinical studies have been made in anti-oxidant and pigment-reducing containing agents.

Conclusion: The exciting and potentially innovative field of cosmeceuticals needs to be substantiated by more peer-reviewed scientific studies regarding their safety and efficacy as anti-aging rejuvenating agents. This would grow their credibility and adoption by clinicians and consumers.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Demonstrate how a unique nanofat biocreme improves outcomes of laser treatments.

Introduction: Topical tissue regeneration using nanofat as an adjunct with a fractionated 1550-nm erbium/1927-nm thulium, CO2 fiber laser and in combination with fat grafting is a new concept within cosmetic surgery. Resurfacing devices have been used in combinations with fat grafting and PRP, however, the use of nanofat as post-laser topical crème is a novel concept developed by our group in 2015.

Materials / method: A total of 50 patients were treated with the Fraxel Dual Laser followed by application a topical nanofat biocrème. Fat was harvested from the thigh region and micronized to produce a Nanofat product. The Nanofat was then compounded with Lipoderm, a transdermal delivery vector, to produce the topical biocreme (patent pending). Biopsies were performed after consent in two patients and examined for histological changes. Pre/post photos of a historical group of 84 patients treated with only the Fraxel Dual Laser were compared to those patients treated with the same laser and nanofat.

Results: The histologic findings of the skin biopsies revealed a greater amount of new elastin fibers as well as a slight increase in the thickness of the epidermis on the skin that was treated with the Nanofat biocrème. With the exception of wrinkles in Fitzpatrick 1, patients having Nanofat biocreme showed 1-2 point improvements over historical controls in the degree of wrinkling, nasolabial fold depth and skin texture across all skin types compared to fractional laser treatment alone.

Conclusion: This preliminary study using transdermal delivery of nanofat in a specially formulated, topical cream (neo-UTM, patent pending) that is applied post fractional laser treatment improves fine lines, depth of nasolabial folds and overall texture of the tissue to a greater degree than laser alone. Moreover, compared to historical controls, patients reported faster healing and ongoing improvement in skin thickness and texture greater than 6 months after treatment.
 

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
Yes
Please specify entities (individual, company, society): lipocube- shareholder, royalties: Tulip- royalties; Millenium Medical- royalties, options

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
Yes
Please specify date...: January 28, 2019
and status : nanofat biocreme (biological creme and methods of use)

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Attendees will learn topical cosmeceuticals for hyperpigmentation

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability