IMCAS Asia 2025
Program

Objectives: This presentation aims to explore the clinical benefits, mechanism of action, and treatment outcomes associated with Tixel®, a novel device utilizing Thermo-Mechanical Fractional Injury (TMFI) technology. The specific objectives are: (1) to highlight the anatomical relevance of the papillary dermis in facial rejuvenation; (2) to demonstrate how TMFI targets this layer to stimulate collagen remodeling and enhance skin quality; (3) to evaluate treatment outcomes through a retrospective clinical review; and (4) to discuss Tixel’s secondary role in transdermal drug delivery.

Introduction: The architecture of the skin is fundamental to facial aesthetics. Each anatomical layer plays a distinct role in maintaining the structural integrity and appearance of the skin. The papillary dermis is responsible for skin texture, firmness, and elasticity due to its rich population of fibroblasts and ECM components. As such, it serves as a key target in modern skin rejuvenation therapies. Tixel®, based on Thermo-Mechanical Fractional Injury (TMFI) technology, delivers controlled thermal energy via a heated titanium tip in a non-ablative manner.

Materials / method: A retrospective clinical analysis was performed on patients treated with Tixel® using TMFI technology for indications including skin aging, textural irregularities, and dermal laxity. Evaluation methods included standardized clinical photography, objective assessments of skin texture and elasticity, and validated patient-reported satisfaction surveys. Treatment protocols were assessed in conjunction with a review of literature, aiming to contextualize TMFI’s unique mechanism of action and its clinical value within the broader field of energy-based dermatologic devices.

Results: Treatment with Tixel showed consistent improvements in skin texture, elasticity, and radiance. Clinical photography and objective assessments confirmed visible smoothing of fine lines and enhanced dermal tone. Patient satisfaction was high, with minimal reports of discomfort or extended downtime. The outcomes aligned closely with published data, reinforcing TMFI’s efficacy in stimulating dermal remodeling through targeted thermal injury while preserving skin surface integrity.

Conclusion: Effective skin rejuvenation requires precise targeting of distinct anatomical layers using EBDs that harmonize with skin physiology. Tixel offers a scientifically grounded and clinically validated method for improving skin texture and elasticity. Its non-ablative nature ensures minimal recovery time, while its ability to enhance topical drug absorption broadens its therapeutic potential. Tixel exemplifies the convergence of precision and performance in aesthetic dermatology, providing reproducible outcomes with a high safety profile across varied skin types.

Disclosures

Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): NOVOXEL - KOL

Were you provided with any honoraria, payment or other compensation for your work on this study?
Yes
Please specify entities (individual, company, society): NOVOXEL - KOL

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work is presented thanks to the support of: NOVOXEL - KOL