Objectives: To present a novel clinical approach to skin rejuvenation using photobiomodulation through Novion, a non-invasive near-infrared light-based system. The goal is to demonstrate that cellular and tissue-level regeneration can be triggered without causing thermal injury, pain, or downtime. This approach targets mitochondrial activation and biochemical signaling, aiming to shift the paradigm from destructive laser-based resurfacing to biologically guided rejuvenation. The objective also includes identifying how specific wavelengths and continuous thermal emission can influence fibroblast function,
Introduction: Traditional energy-based devices rely on selective photothermolysis—deliberately damaging tissue to stimulate repair. However, this can cause pain, downtime, and potential complications. Photobiomodulation (PBM) offers a fundamentally different concept: using light as a biological signal rather than a destructive force. Novion introduces plasma-based incoherent NIR light filtered to 1064nm, which penetrates deeply and safely. By stimulating cytochrome c oxidase within mitochondria, Novion enhances ATP production, nitric oxide release, and calcium influx. This cascade initiates regeneration wit
Materials / method: Novion emits filtered continuous-wave near-infrared light (≥1064nm) using a plasma-derived incoherent light source. The system includes a sapphire cooling tip to protect the epidermis while allowing heat to accumulate in the dermis (45–60°C). Treatments target areas with loss of volume, elasticity, or tone. The photonic energy is absorbed by cytochrome c oxidase, triggering mitochondrial activation and downstream signaling. Additionally, calcium channels are stimulated, leading to expression of growth factors, cytokines, and HSPs. The method is applied in outpatient settings with no anesthesia
Results: Clinical observations show improved skin tone, texture, elasticity, and pore reduction after a series of Novion treatments. Histologically, fibroblasts appear more active with enhanced collagen and elastin deposition. Patient feedback reports high satisfaction, particularly due to the absence of pain or recovery time. Real-time imaging and infrared thermography confirm deep, controlled dermal heating without epidermal damage. Notably, improvements are progressive, indicating cumulative biological effects. Cases also demonstrated reduction in inflammation markers and signs of vascular remodelin
Conclusion: Novion demonstrates that photobiomodulation, when delivered precisely through continuous NIR light, can activate the skin’s regenerative mechanisms without injury. By stimulating mitochondria and initiating intracellular signaling, tissue can be remodeled safely, comfortably, and repeatedly. This challenges the conventional laser-based model of "destroy to renew," offering instead a "stimulate to restore" philosophy. Novion represents a new class of skin energy systems that combine biology and physics to achieve visible, long-term rejuvenation with minimal risk and maximal compliance.
Disclosures
Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): yumeco
Were you provided with any honoraria, payment or other compensation for your work on this study?
No
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work is presented thanks to the support of: Mr. Mark