Objectives: Recent evidence suggests that cells of human scalp, including those in associated appendages like hair follicles, are impacted by physiologic aging. This talk will examine how aging affects different fibroblast populations in the inter-follicular, follicular and peri-follicular dermis, and hair follicular cells including melanocytes.

Introduction: Like other complex body tissue systems that are composed of several distinct cell types, the scalp hair follicle is prone to broadly similar processes that determine functional longevity. The hair follicle is somewhat unusual however, in that some of its interactive cellular systems appear to be non-essential for its overall survival. For example, follicular melanogenesis can cease without much consequence to hair fiber production, and strikingly, age-associated gray/white hair follicles may even show more vigorous growth than their pigmented predecessors.

Materials / method: Scalp aging is thought to be associated with significant change in the functional integrity of the dermis, and we and others propose that this may impact hair growth as the follicular mesenchyme is integrated into the peri-follicular dermis. A range of bioscience research techniques were used in these studies, where human scalp tissue and derived cells, protein and DNA were used to address this question.

Results: Excluding the follicular mesenchyme (papilla and sheath), at least two other distinct fibroblast populations are found in scalp dermis. Excluding the follicular mesenchyme (papilla and sheath), at least two other distinct fibroblast populations were detected in scalp dermis. Aging affects fibroblasts in the superficial ‘papillary’ dermis and deep ‘reticular’ fibroblasts. While numbers of the former drop significantly in aging skin, aging also affects reticular fibroblasts that function in the wound healing/scar formation/adipocyte differentiation response.

Conclusion: The concept of 'tissue skeleton' network has recently been proposed that connects extracellular matrix to cell nucleus leading to changes gene expression. We and others have examined whether age-related changes can be detected in follicular and peri-follicular scalp dermal fibroblasts, as well as in the melanocytes of the hair bulb, and this talk will examine how physiological aging may impact of scalp and associated hair growth.

Disclosures

Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): Unilever, Procter & Gamble, Aveda

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Can approach and treat patients with Telogen effuvium.

Introduction: Telogen effuvium (TE) is the common type of diffuse hair loss in both men and women. It can be acute or chronic (more than 6 months). Diagnosis requires detailed patient history, physical examination, and laboratory tests. Scalp biopsy may be needed and should be evaluated by an experienced dermatopathologist.

Materials / method: For most patients, TE is self-limiting and reversible when underlying causes are identified. But in some patients, it is idiopathic and long standing. Management can be challenging especially in chronic TE. There is no medication approved by FDA for treatment of TE. Topical minoxidil, oral minoxidil, topical corticosteroid and systemic corticosteroid have been reported as options. Some of these treatments are controversial. In my opinion, they can be considered in severe or chronic TE.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability