Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): GliSODin / Isocell

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work is presented thanks to the support of: GliSODin

Objectives: To measure the efficacy of the combination of oral antioxidants in inhibiting AhR nuclear translocation in keratinocytes exposed to cigarette smoke.

Introduction: Air pollution figures among the leading extrinsic causes of skin aging. Particulate matter, ozone, and PAHs play a central role by triggering the formation of ROS and, therefore, cell damage. Researchers are continually looking for therapeutic alternatives to avoid or retard this process. One promising strategy is inhibiting the Ah receptor (AhR) translocation. Nutraceuticals have been studied for anti-aging purposes, and a recent in vitro study measured the efficacy of the combination of oral antioxidants in inhibiting AhR nuclear translocation in keratinocytes exposed to cigarette smoke.

Materials / method: Cultures of human keratinocytes were incubated with 3 non-cytotoxic concentrations of the evaluated nutraceutical for 48 hours and exposed to cigarette smoke for further quantification of the Ahr receptor in the cytoplasmic lysate.

Results: The evaluated product protected the nuclear translocation of the AhR receptor, allowing us to infer that it exerts a protective effect against the deleterious effects of the xenobiotic pollutants. These findings demonstrate that the evaluated product may help to decrease and attenuate the aspects and signs of skin aging produced by constant exposure to extrinsic agents, in particular, cigarette smoke.

Conclusion: Even though the problem of pollution cannot be solved in a short-time period, there are alternative ways to tackle the degrading consequences to human health.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work is presented thanks to the support of: FQM MELORA