Objectives: Understand the main features of the disease, the challenges with the treatments and how to choose between antibiotics and biotherapies.
Introduction: As HS is both an infectious and auto-inflammatory disease, treatments can be both antibiotics and anti-cytokines antibodies, mainly anti-TNF-alpha. Surgery is also an important option which will be discussed in another session.
Materials / method: Review of the literature ans experience of RESOVERNEUIL in France (french network for HS).
Results: The main protocol is the association of rifampicin / clindamycin. Many protocols have derived now from this historical one: rifampicin / ofloxacin; rifampicin / moxifloxacin / metronidazole in induction phase, and then cotrimoxazole in maintenance phase. For biologics, the anti-TNF adalumimab in the only one to have an agreement in Europe. But many new molecules are under investigation: anti-IL-17 (secukinumab), anti-IL-23 (guselkumab), anti-complement fractions (anti-C5a). The field of treatments is now increasing every year.
Conclusion: The best option depends on the main clinical presentation: purulent or rather inflammatory phase. In a same patient, treatment can change depending on a particular phase of the disease. It remains anyway a multidisciplinary approach.
Disclosures
Did you receive any funding to support your research for this TOPIC?
No
Were you provided with any honoraria, payment or other compensation for your work on this study?
No
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work was not supported by any direct or non direct funding. It is under the author's own responsability