Objectives: - Understand the role and mechanism of action of PBSerum recombinant enzymes (collagenase, lipase and lyase) and HMWHA in the management of fibrosis-related pathologies.
- Establish the possible causes of fibrosis development and scar tissue formation: diagnostic approach and treatment strategy based on PBSerum recombinant enzymes and HMWHA.

Introduction: The use of recombinant enzymes along with HMWHA in the treatment of diverse skin problems is generating an increasingly significant interest thanks to their differential advantages over other active principles. While HMWA has proven efficacy in the prevention and treatment of fibrosis, enzymes are very selective molecules that catalyze metabolic reactions, being specific for a substrate on which they act without damaging adjacent structures. This specificity reduces the possibility of having any complication or adverse effect and it is responsible for their high security and efficacy level.

Materials / method: - PBSerum recombinant enzymes (collagenase, lipase, lyase)

- High Molecular Weight Hyaluronic Acid

Results: HMWHA decreases the rate of the fibrosis in affected tissues, playing a key role in its prevention and treatment.

Recombinant enzymes have proven efficacy in the treatment of diverse skin pathologies: fat accumulation, cellulite, flaccidity, scars, fibrosis… The clinical practice has revealed that they degrade specifically the substrates that mainly cause them (collagenase removes atrophic collagen fibers that lead to flaccidity and fibrosis, lipase degrades TG inside the adipocyte reducing fat accumulation and lyase acts in synergy with the other enzymes as a vehicle to help their expansion)

Conclusion: The combination of PBSerum recombinant enzymes with HMWHA have shown very favorable and encouraging results that may change the approach in the way certain skin pathologies have been treated so far.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability