Objectives: The author decided to treat damaged skin emanating from burns and dermal induced vascular occlusion (devoid of bleeding and release of growth factors, signal messengers etc.) with potential to dermal scarring with ethical stem cells, signal messengers (USCs), growth factors (PRP) and an activating source (LLLT) to see whether it accelerated recovery and prevented scarring. I can see no literature references to whether this was done before
Introduction: : LLLT can either act directly on cells or initiate the release of specific mediators. Epithelial mesenchymal transition (EMT) occurs when epithelial cells lose their characteristics and become mesenchymal. These mesenchymal cells can return to an epithelial phenotype by mesenchymal-epithelial transition.
Materials / method: Adipose Stem Cells initially harvested from VASER
LED lamps for light therapy were provided by Omnilux, Birmingham UK, who developed in partnership for PDT with Cancer Research UK
Umbilical Stem Cells were provided without financial benefit from CellResearchCorp based in Singapore
Laser resurfacing provided by ActiveFx by Lumenis
Results: LLLT can either act directly on cells or initiate the release of specific mediators. Epithelial mesenchymal transition (EMT) occurs when epithelial cells lose their characteristics and become mesenchymal. These mesenchymal cells can return to an epithelial phenotype by mesenchymal-epithelial transition.
Conclusion: Dermal papilla cells irradiated by 633nm red light enhance keratinocyte proliferation, suggesting enhanced epithelial-mesenchymal interaction. The author advances theory that this process advances the production of epidermal tissue in the presence of a cell source and autologous and external signal messengers in patients traumatised in the absence of normal bleeding repair
Disclosures
Did you receive any funding to support your research for this TOPIC?
No
Were you provided with any honoraria, payment or other compensation for your work on this study?
No
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work was not supported by any direct or non direct funding. It is under the author's own responsability