Disclosures

Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): Skinceuticals

Were you provided with any honoraria, payment or other compensation for your work on this study?
Yes
Please specify entities (individual, company, society): Skinceuticals

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
Yes
Please specify entities (individual, company, society): Skinceuticals

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work is presented thanks to the support of: Vydence and Skinceuticals

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Skin wrinkling is one of the most prominent signs of aging skin and one of the most important targets in antiaging therapy. Mechanically, human skin appears as a multilayer composite containing the stiff thin cover layer of stratum corneum followed below by more compliant layers of viable epidermis and dermis and further below by much more compliant layer of sWAT. Recently, I. Kruglikov et al. have argued that skin wrinkling must be substantially dependent on the quality of the interfaces between the single skin layers, especially of the ED and DS junctions

Introduction: It was hypothesized that the basement membrane acts as a physical barrier to retain HA in the epidermis. The deterioration of the BM at the DEJ of organotypic human eyelid skin and abdominal skin after UVB exposure is blocked by treatment with both the MMP inhibitor CGS27023A and the heparanase inhibitor BIPBIPU. Therefore, the HA content in the epidermis and the ultrastructure of the basement membrane of organotypic human skin were examined after UVB exposure following treatment with MMP and heparanase inhibitors.

Materials / method: To investigate the distribution of HA in the SE model, HA contents in the epidermis, dermis, and cultured media of the SE model were evaluated by Shunsuke Iriyama et al in the presence of MMP and heparanase inhibitors. HA was increased in the epidermis and unchanged in the dermis following treatment with the MMP and heparanase inhibitors. Meyer and Stern found that no HA was detectable in the epidermis of senescent skin from an 81-years old subject. On the other hand, severe disruption and multilayered reduplication of the lamina densa have been observed in the cheek skin of 60-years old men

Results: One of the ways of acting on described processes is using EBD, for example Ultrasound and Radiofrequency (RF). RF currents belong to the state-of-the-art treatments in noninvasive and minimal invasive aesthetic medicine. Application of RF current can induce mechanical stress on the interfaces between single layers , which are involved in the maintenance of mechanical properties of the skin and are known to be strongly modified in aging. Two most prominent skin interfaces are EDJ and DSJ, containing papillary fibroblasts and dermal fibroblasts and subcutaneous adipocytes, respectively

Conclusion: Mechanical modification of the skin interfaces is connected to modulation of caveolin-1 (Cav-1) expression. Cav-1 is a principle structural component of the caveola plasma membrane invaginations, which are present in almost all types of skin cells and adipocytes. Whereas future research in this field will be needed, we propose that interfacial therapy targeting EDJ and DSJ can be an effective method in antiaging and cellulite treatments.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability