Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
Yes
Please specify entities (individual, company, society): MAGE Biotech

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
Yes
Please specify entities (individual, company, society): recure ltd

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
Yes
Please specify date...: in progres
and status : 2022

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: To compare the lifting effects of intradermal injection of BTXA and the lifting effects of exosome combined with the intradermal injection of BTXA.

Introduction: In recent years, intradermal injection of BTXA has been reported to be effective for treating wrinkles due to skin lifting. The mechanism of action behind the intradermal injection of BTXA has been accredited to the induction of fibroblast contraction and the stimulation of collagen production. Exosomes have recently gained much attention for their effects on promoting the regenerative and restorative capacity of aged or damaged skin. Exosomes are hypothesized to improve keratinocyte and fibroblast function, enhancing collagen and elastin synthesis, and increasing dermal fat.

Materials / method: The skin-lifting effects of the intradermal injection of BTXA and the skin-lifting effects of exosome combined with the intradermal injection of BTXA were examined by conducting a side-by-side study with 30 female subjects between the ages of 30-60. One side of the subjects’ faces was injected only with BTXA. The other side of the subjects’ faces was injected using a combination protocol of exosome with the intradermal injection of BTXA. The skin lifting effectivenesses of both protocols was analyzed using Quantificare 3D LifeViz Mini.

Results: When analyzed using Quantificare 3D LifeViz Mini, the sides treated with the combination of exosome and botulinum toxin showed more lifting up to 4mm when compared to the sides treated with only botulinum toxin.

Conclusion: The results from this study demonstrated the lifting effects of exosomes. The combination treatment of exosome with the intradermal injection of BTXA provides a comprehensive solution to the treatment of facial wrinkles and anti-aging.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): Rion Aesthetics

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No
Please specify entities (individual, company, society): Rion Inc, Rion Aesthetics

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
Yes
Please specify date...: Granted and Pending
and status : 2016-2023

This work is presented thanks to the support of: Rion Inc

Disclosures

Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): rion

Were you provided with any honoraria, payment or other compensation for your work on this study?
Yes
Please specify entities (individual, company, society): rion

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability