Objectives: To provide an overview of on the latest developments in the following topics:
- UV filters and visible light photoprotection
- Biological photoprotection
- Novel Formulations
- Personalized photoprotection

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
Yes
Please specify entities (individual, company, society): Investigator: Incyte La Roche-Posay Pfizer PCORI Consultant: ISDIN Beiersdorf Ferndale L’Oréal Eli Lilly Zerigo Health Skinosive Kenvue Speaker, educational session: La Roche-Posay Cantabria labs Pierre Fabre NAOS Uriage Pfizer ISDIN

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Topic can be included in several sessions - I can adjust

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: New advances in the treatment of skin cancer

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Ablative laser therapy is effective for keratinocyte carcinoma reduction. Ablative fractional lasers also have evidence for reducing precancerous growths, likely through induction of IGF-1 signaling and normalization of an appropriate UVB response in aged skin. Recent data suggests non-ablative fractional lasers may reduce the risk of subsequent facial skin cancer in those with a history of a prior facial keratinocyte carcinoma.
Review the mechanisms by which laser rejuvenation results in healthier skin quality and may reduce the risk of future skin cancer.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: During photodynamic therapy (PDT) of actinic keratosis, either aminolevulinic acid (5-ALA) or methyl aminolevulinate (MAL) is utilized as precursor that preferentially accumulates in dysplastic cells. The precursor then converts to Protoporphyrin IX (PpIX) via the heme pathway and causes apoptosis of the cells when illuminated.

Introduction: The major drawback of PDT is the pain experienced during the illumination. In fact, though ALA or MAL are not taken up into the nerve endings, reactive oxygen species produced during light exposure may cause cell degranulation of mast cells leading to release of inflammatory mediators. Among them, bradykinin and histamine are known to directly stimulate sensory nerve endings.

Materials / method: When using ALA or MAL, it is important to avoid the confusion between incubation time and Drug Light Interval (DLI). When performing ALA-PDT or MAL-PDT, DLI is the period of time between first PpIX production by dysplastic cell and its activation by light. Studies of intracellular PpIX formation kinetics have demonstrated that PpIX formation by dysplastic cells is quasi-instantaneous after 5-ALA administration. Since ALA or MAL is not removed, formation of PpIX will continue as long as the dysplastic cell is alive.

Results: Short DLI are associated with reduced PpIX buildup in target tissue due to absence of PpIX diffusion into surrounding tissues containing intact sensory nerve fibers.

Consequently, short DLI should be used since it is a very simple way to reduce pain. Several clinical studies have confirmed the advantage of using short DLI.

Conclusion: Mordon S. Painless and efficient ALA-PDT and MAL-PDT of actinic keratosis can be achieved by drastically reducing the drug-light interval. Dermatol Ther. 2020 May;33(3):e13423.
Gandy J, Labadie B, Bierman D, Zachary C. Photodynamic Therapy Effectively Treats Actinic Kera

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability