Laboratoires VIVACY

Expectations from cosmetic treatments have never been higher*: with lip corrections proving to be very popular. "Ageing gracefully" is becoming an essential preoccupation! Aim: to ward off the effects of time! 16% of women who are worried how their skin looks (due to their age) think that their lips lack volume, of whom 25% are over the age of 60**. The importance of looking good for the younger generation lies in their search for perfection. With the rise of social media and influencers, women's requirements have changed. Young people, called "millennials", are turning to cosmetic treatments and they are increasingly looking to have fuller, plumper lips. The lips communicate a large amount of information and emotion to those around us. As we age, the lips have a tendency to***: • Get thinner and lose volume • Become dehydrated • Lose definition (contours are less well-defined and can therefore change the expression on your face) Moreover, some patients can have asymmetric lips, either from birth or as a result of surgery***. STYLAGE® Special Lips has been specially designed to treat all indications related to the ageng of the lips. Its is also available with a local anaesthetic, Lidocaine, for a greater comfort during the procedure. • Lip volume augmentation. • Rehydration of the lips • Definition of lip contour INJECTION PLAN: Injection into and around the labial mucosa using conventional techniques (retrograde tracing, micro-bolus). * Monnet-Corti, V. Antezack, A. Pignoly, M._Comment parfaire l’esthétique du sourire : toujours en rose !_L’Orthodontie française_2018 ; 89(1) : 71-80 ** Aesthetic Dermatology Study 2018, Quantification and French Market Potential: Treatments at Clinic and Treatments at Domicile. 2nd Edition, organised by ARCANE research with 824 women aged between 18 and 75 years old who have already had at least once an aesthetic dermatological treatment. Questioned between February 15th and March 6th 2018. *** Schweiger, E. S. et al. "Successful Treatment with Injected Hyaluronic Acid in a Patient with Lip Asymmetry after Surgical Correction of Cleft Lip". Dermatol. Surg., 2008 ; 34 : 717-719 / Born, T._Hyaluronic Acids_Clinics in Plastic Surgery_2016 ; 33(4) : 525-538

FACIAL REMODELLING: MORE THAN JUST A TREND Over the last few years, repairing volume loss caused by facial ageing has evolved considerably*. Restoring lost volume has become a main priority for a large number of patients. Laboratoires VIVACY has found the answer by adopting a more global approach to facial ageing through the development of “volumising” products. With the help of injections containing a hyaluronic acid-based volumising product, it is now possible to redefine facial contours, but also to restore volume to the most affected areas**. Wrinkles are not the only effects of facial ageing. Over time, the face undergoes anatomical and functional changes due to the loss of superficial and deep fat. STYLAGE® XL and XXL are injectable hyaluronic acid volumizers specifically designed to restore volume to the face that are lost over time. They are high density volumizer gels that can be injected into the deep dermis or subcutaneous tissues to restore fullness, balance and harmony to the face and tighten sagging skin. • Fill sunken temples • Enhance flat cheekbones • Redefine sagging jawline • Improve chin shape * Rohrich, J. et al. Lift-and-fill Face Lift: integrating the Fat Compartments. Plastic and Reconstructive Surgery, 2014. ** Sadick, N. S. A Novel Approach to Structural Facial Volume Replacement. Aesth Plast Surg., 2013 Bass, L. S. Injectable Filler Techniques for Facial Rejuvenation, Volumization and Augmentation. facial Plast Surg Clin N Am 23 (2015) 479-488

DESIRIAL® is a fluid hyaluronic acid-based injectable gel designed to restore hydration, elasticity, tonicity and sensitivity to the vulvo-vaginal area. It is also used to treat vaginal dryness. As the tissues in the vagina start to change, discomfort or a burning feeling may occur, as well as increased sensitivity or chronic irritation and itching, which in time may cause sores. To help counteract these symptoms, Hyaluronic Acid is injected directly into the affected area to limit dryness in the vaginal mucous and improve tissue quality. When injected, the hyaluronic acid gel directly enters the vulvo-vaginal tissues and efficiently helps rehydrate the zone. The product injected then indirectly creates a mechanical pressure on the cells in the vaginal mucosa, which in turn, stimulates their activity. Through the stimulation of these cells, the synthesis of collagen and elastin fibres is boosted and therefore helps improve the overall quality of the vulvo-vaginal mucosa*. 94% of women have seen an improvement or significant improvement to their quality of life, up to 6 months after treatment with DESIRIAL®**. Indications: - Intimate dryness - Vaginal discomfort - Chronic irritation * Quan T et al, : Enhancing structural support of the dermal microenvironment activates fibroblasts, endothelial cells, and keratinocytes in aged human skin in vivo. J Invest Dermatol. 2013 Mar;133(3):658-67. doi:10.1038/jid.2012.364. Epub 2012 Oct 25. ** A post-marketing follow-up non-interventional, open-label prospective study evaluating the efficacy and safety of DESIRIAL® in its indications for use. Visits at 1 month, 3 months, 6 and 12 months post-injection. The study included 52 patients treated with DESIRIAL®. 42% of the patients had a retouch following the injection. Efficacy parameters evaluated for DESIRIAL® parameters evaluated by the patient: symptoms (dryness, irritation / burning sensation during daily life and sport, itching, dyspareunia), and parameters evaluated by the doctor: vaginal PH, tissue quality (cutaneous and mucous membrane atrophy) and symptoms (abrasions, inflammation, edema, petechiae / bleeding). Treatment-related adverse events described in the leaflets have been reported. These were mainly hematoma / bruising, pain / tenderness / injection pain, swelling / edema, skin rash / erythema. No serious adverse events were reported.

STYLAGE® Hydro & STYLAGE® HydroMax are indicated to improve skin moisture and elasticity at the dermoepidermal junction and in the superficial dermis of the face, neck, décolleté or back of the hand, and in the case of STYLAGE® HydroMax specifically, the deep dermal layers of the face and back of the hand. They are specifically designed to restore optimal level of skin hydration and improve its elasticity and firmness. STYLAGE® HYDRO • Treatment of moderate dehydration and skin laxity • Skin elasticity improvement • Revitalization of the face, neck and décolleté area and hand rejuvenation STYLAGE® HYDROMAX • Treatment of Intense dehydration and skin laxity • Skin elasticity improvement • Revitalization of the face, neck and décolleté area and hand rejuvenation

Hyaluronic acid is a key component of the skin structure (1) which plays a vital role in maintaining skin moisture and elasticity, as well as tissue cohesion. As the years go by, collagen production and the amount of hyaluronic acid naturally present in the dermis begin to decrease. The skin loses its firmness and elasticity and becomes visibly drier, resulting in more noticeable expression lines (crow’s feet & frown and forehead lines) associated with the first signs of sagging (hooded eyes, lip wrinkles, loss of definition of the facial contour) and incipient loss of subcutaneous fat tissue (dark circles, tear trough, accentuation of nasolabial folds). The STYLAGE® range comprises different formulas designed for the treatment of all types of wrinkles, from the finest to the deepest: - Superficial lines (STYLAGE® S) - Moderate to deep lines (STYLAGE® M) - Deep to very deep lines (STYLAGE® L) (1) Manuskiatti W, Maibach HI. Hyaluronic acid and skin: wound healing and aging. Int J Dermatol 1996; 35: 539–544.

THE SCIENCE OF ANTI-AGEING Laboratoires VIVACY offers a professional quality dermo-cosmetics skincare line, curated using innovative expert formulas to preserve the youthful qualities of your skin. The dermo-cosmetic products include an exclusive technology which comes from Laboratoires VIVACY’s advanced research: The VIVASÔME® Complex, an anti-age trilogy. The VIVASÔME® Complex is based on the principle of carrying encapsulated active components via liposomes. Comparable to little “beads”, their structure resembles the hydrolipidic (1) film of the skin. (1) The hydrolipidic film is a protecting film that completely covers the skins surface. It is mainly made up of sweat and sebum, and its principal role is to defend the skin against bacteria, acting as an external protecting barrier. It also allows the skin to maintain its suppleness and hydration.

DESIRIAL® PLUS is a more elastic gel designed to remodel the Labia Majora which has lost partial volume (hypotrophy) or total volume (atrophy). One of the main improvements, apart from an aesthetic point of view, is the protection of the Labia Minora. After a certain age, the tissues tend to shrink, especially in the outer lips, which can lead to a decrease in natural protection of the vulva and localised pain. The hyaluronic acid gel recreates volume, thus protecting the area once again DESIRIAL® PLUS allows you to restore volume loss in the Labia Majora, improving patient comfort and their quality of life. Through this treatment, the volume restored to the outer lips acts as a protective barrier for the vagina. The improvement and preservation of quality of life is an important benefit linked to this intimate care treatment, and can be appreciated rapidly after the first appointment. Indications: - Hypotrophy, atrophy of the labia majora (volume loss) - Aesthetic concerns 93% of women have seen an improvement or significant improvement to their quality of life, up to 12 months after treatment with DESIRIAL® PLUS*. * A post-marketing follow-up non-interventional, open-label prospective study evaluating the efficacy and safety of DESIRIAL® Plus in its indications for use. Visits at 1 month, 3 months, 6 and 12 months post-injection. The study included 35 patients treated with DESIRIAL® Plus (with or without DESIRIAL®). 37% of those treated with DESIRIAL® Plus had a retouch following the injection Efficacy parameters evaluated for DESIRIAL® Plus, parameters evaluated by the patient: aesthetic perception and symptoms (irritation/burning sensation during everyday life and sport, itching) and the parameters evaluated by the doctor: skin atrophy of the labia majora, volumising and trophic effect, GAIS. Patient and physician satisfaction and improved quality of life were also collected for the 2 treatments. Treatment-related adverse events described in the leaflets have been reported. These were mainly hematoma / bruising, pain / tenderness / injection pain, swelling / edema, skin rash / erythema. No serious adverse events were reported.