Objectives: Explore the efficacy of two protocols on resistant AGA, focusing on hair density, thickness, and patient satisfaction. Aims to determine if integrating low-dose oral minoxidil, microneedling, LLLT, modified PRF, and botulinum toxin A enhances treatment outcomes over conventional methods.
Introduction: The persistent challenge of treating resistant Androgenic Alopecia (AGA) has led to exploring multi-modal therapeutic approaches. This study assesses the efficacy of combining low-dose oral minoxidil, microneedling, low-level laser therapy (LLLT), modified platelet-rich fibrin (PRF), and botulinum toxin A.
Materials / method: Study included 45 patients with AGA, divided into two groups. Group A received oral minoxidil (2.5 mg daily), botulinum toxin A (2.5 IU), microneedling with modified liquid PRF, and LLLT (630 nm for 30 minutes) in 4 sessions over 12 weeks, plus daily home-based LLLT. Group B followed the same minus botulinum toxin A, using saline instead. Assessments were at weeks 16 and 36.
Results: At week 16, Group A saw a 21% increase in hair density and 13% in thickness; Group B had 10% and 8%, respectively. By week 36, Group A maintained a 25% density increase and 15% thickness; Group B showed 12% and 10%. Though thickness differences weren’t statistically significant (p>0.05), density and scalp appearance improvements were (p<0.01). Patient satisfaction and quality of life scores were significantly higher in Group A, indicating a notable preference for the comprehensive treatment approach.
Conclusion: The study underscores the enhanced effectiveness of the combined treatment protocol for resistant AGA, emphasizing the potential of integrating botulinum toxin A for superior outcomes. Further research is warranted to validate these findings.
Disclosures
Did you receive any funding to support your research for this TOPIC?
No
Were you provided with any honoraria, payment or other compensation for your work on this study?
No
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work was not supported by any direct or non direct funding. It is under the author's own responsability