Objectives: This presentation focuses on lasers using Fractional Photothermolysis (FP) technology to rejuvenate and enhance the youthfulness of our skin. FP creates Microscopic Treatment Zones (MTZ) while sparing the surrounding skin, facilitating faster re-epithelization of the treated area. I will discuss about the historical background and advancements in Ablative Fractional Laser (AFL), Non Ablative Fractional Laser (NAFL) and Hybrid lasers. Additionally, it will discuss strategies for optimizing outcomes for patients undergoing skin rejuvenation treatments.