IMCAS World Congress 2025
Program

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
Yes
Please specify entities (individual, company, society): Jetema and Xytide Biotech

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
Yes
Please specify entities (individual, company, society): Jetema and Xytide Biotech

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work is presented thanks to the support of: Jetema and Xytide Biotech

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work is presented thanks to the support of: Jetema

Objectives: 1. To understand that the midfacial aging is multifactorial which cannot be fixed completely by volume replacement only.
2. To prove that 3 'R' technique is an effective approach for midface rejuvenation in the Asian population.
3. To evaluate a long-term F/U after combined procedures of HA filler injections and PDO thread lifting.

Introduction: The combination of hyaluronic acid (HA) fillers and polydioxanone (PDO) thread lifting is gaining popularity for midface rejuvenation, especially among the Asian population. Despite the common use of these techniques, there is a paucity of long-term studies assessing their combined efficacy and safety. This study aims to evaluate the efficacy and safety of combined HA filler and PDO thread treatment for midface rejuvenation over a 24-month period in a Korean population.

Materials / method: This prospective, blinded, single-center, open-label trial included 11 Korean subjects, aged 29–70 years, with mid- face volume loss graded 1–4 on the anteromedial cheek fullness scale. Participants were treated with crosslinked HA dermal fillers and PDO threads using 3’R’ technique. Assessments were conducted using the Global Aesthetic Improvement Scale (GAIS), investigator-led clinical evaluations, and volumetric measurements using the Morpheus 3D system at baseline, 6, 12, and 24 months post-treatment.

Results: Quantitative analysis revealed a significant reduction in midface width from an average baseline of 149.27–145.00 mm at 24 months (p < 0.00001). Similarly, lower face width decreased from 130.36 to 117.27 mm at 24 months (p < 0.00001). The GAIS scores demonstrated high levels of subject satisfaction, with 9 out of 11 patients reporting consistent satisfaction or improvement over 24 months. Minimal adverse events were reported, and no serious complications occurred.

Conclusion: 1. The combination of HA fillers and PDO threads was effective in achieving and maintaining long-term improvements in facial volume and contour.
2. The Morpheus 3D system provided objective volumetric data, which supported the subjective improvements observed by patients and investigators.
3. The study results highlight the benefits of ongoing neocollagenesis and tissue remodeling beyond the dissolution period of the materials.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability