Objectives: There can be a difference in effectiveness of thread lifting depending on thread number, diameter, the presence of barbs, barb types, needle types, the location of threads, and patients’ condition. There is no well-designed study regarding efficacy difference according to those factors. I will discuss the histologic and biomolecular differences among the various absorbable threads and the infection that physicians can experience during the process of thread lifting.
Introduction: Antiaging has become a very popular aspect in the field of dermatology. Conventional nonsurgical procedures including botulinum toxin and filler injections have their limitations in improving deep wrinkles and decreased tissue laxity. Recent esthetic procedures have focused more on safety, ease of procedure, effectiveness and lower risk for side effects. Thus, thread lifting has become a common trend.
Materials / method: Dorsal skin of rat was divided into five different compartments and four different PDO threads and monofilament poly-lactic acid (PLA) thread were inserted. Tissue samples were obtained at week 1, 2, and 12 after the procedure for histopathologic review and real-time PCR for quantification of collagen.
Results: Multiple PDO filaments produced more collagen at 2 weeks. Single-stranded PLA thread insertion resulted in more Col1α1 levels than the double PDO thread and also showed the most Col1α3 production at week 2. The amount of collagen showed a sharp decline at week 12. Histologic evaluation showed retained threads surrounded by fibrous capsule-like structure at week 12.
Conclusion: There was more collagen production in multiple stranded PDO threads compared to a single strand and increasing number of threads leads to more collagen synthesis. However, things like scars at the insertion site, resistence during the procedure, and the infection should be considred in selecting the types of threads.
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