Objectives: Objective: To assess the combined efficacy of Fractional Picosecond Laser (FPL) and plant-derived stem cell exosome therapy for male Androgenetic Alopecia (AGA) treatment.

Introduction: Exosomes play a pivotal role in hair morphogenesis and regeneration, offering novel avenues for alopecia treatments. Particularly, exosomes derived from stem cells exhibit properties that can stimulate hair follicle development and cycling.

Materials / method: This was a pilot study in 5 male participants treated with a 1064-nm FPL for mild-to-moderate AGA and then were applied with topical exosomes. The patients underwent 5 treatments at 4-week intervals, followed by a 4-week post-procedure assessment. Expert panel assessment score and patient satisfaction was assessed using a 7-point scale. Dermoscopic analysis was conducted to evaluate hair shafts. Adverse effects were also monitored.

Results: Significant clinical improvement in hair density and thickness was observed from 1 to 6 months post-treatment, with notable increases in expert panel assessment scores and patient satisfaction. Minimal adverse effects were reported, resolving swiftly. Dermoscopic analysis confirmed the safety of the treatment, showing minimal petechiae without hair shaft damage.

Conclusion: The study underscores the potential of combining 1064-nm FPL with topical plant-derived stem cell exosomes in promoting hair regrowth in male AGA. These findings highlight the role of exosomes in hair follicle development and regeneration, encouraging further research to optimize this promising treatment approach.

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Objectives: Better treatment , less side effects

Objectives: This study aims to evaluate the combined effects of botulinum toxin and exosome therapy on hair loss over one year, utilizing data from twelve cases across four countries following a unified protocol. Additionally, the study explores the results among different races and age groups.

Introduction: Hair loss is a global concern, prompting the exploration of innovative treatments. Botulinum toxin and exosome therapy offer distinct mechanisms of action and show promise in addressing this issue. This study investigates the synergistic effects of combining these therapies, drawing on data from twelve cases spanning four countries. Results among different racial and age groups are also examined

Materials / method: Twelve cases meeting predefined criteria from four countries were enrolled in this study. Participants received combined botulinum toxin and exosome therapy according to a unified protocol. Hair shedding, density, and thickness were evaluated as primary outcomes over a six-month period using standardized criteria

Results: Significant improvements in hair shedding, density, and thickness were observed among participants following the combined therapy. Statistical analysis supported the efficacy of this approach, indicating its potential as a promising treatment for hair loss. Younger patients demonstrated better outcomes, and Caucasians experienced quicker effects compared to Asians. Additionally, positive results were noted among black individuals with curly hair

Conclusion: The findings suggest that combining botulinum toxin and exosome therapy holds promise in addressing hair loss. Integration of this approach into existing treatment regimens may improve outcomes. However, further research, including larger trials and mechanistic studies, is necessary to fully understand its potential and optimize its clinical application.

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