摘要

Objectives: Tissue repair and regeneration critically depend on oxygen availability, yet hypoxia remains a major limitation in biomaterials and wound-healing strategies. Despite advances in scaffolds, dressings, and regenerative matrices, most biomaterials fail to actively address local oxygen deficiency at the tissue interface. M101 is a naturally occurring extracellular hemoglobin derived from the marine annelid Arenicola marina. Unlike mammalian hemoglobin, M101 functions independently of red blood cells, carries up to 156 oxygen molecules, and releases oxygen passively according to local O2 gradient. Introduction: This presentation explores how M101 acts as a functional bridge between biomaterials and living tissues, transforming passive materials into active oxygen-delivering systems. Integrated into gels, dressings, or preservation solutions or cell media, M101 enhances cell survival, supports metabolic activity, reduces ischemia-related damage, and promotes physiological healing processes without inducing oxidative stress. Materials / method: Preclinical and clinical translational data demonstrate that oxygenation mediated by M101 improves tissue viability, accelerates wound healing, and preserves biological integrity in challenging hypoxic environments. By addressing a fundamental yet often overlooked biological need—oxygen—M101 redefines the role of biomaterials from structural support to dynamic biological partners. Results: M101 thus represents a paradigm shift in regenerative medicine and tissue engineering, positioning oxygen as a central therapeutic vector and establishing a missing link between biomaterials and functional tissue regeneration. Conclusion: References : Lancien, Ugo, Mahe, Pierre-Joachim; Lepelletier, Aline; Leize-Zal, Elisabeth; Lantieri, Laurent; Perrot, Pierre. 2025. Hydrogel Containing an Oxygen Carrier With Hemoglobin From the Marine Worm Arenicola marina (M101) in the Management of Deep Burns. Plastic & Reconstructive Surgery-Global Open, 13 (7) 1-4 Awan, Tamer; Lhuaire, Martin; Lantieri, Laurent. 2024. Use of HEMHealing, an Oxygenating Dressing in the Treatment of a Full-thickness Burn on the Fingertips. Plastic & Reconstructive Surgery-Global Open, 12 (8) 1-4