摘要

Objectives: To compare the responses of patients treated with cryolipolysis alone versus those who combined cryolipolysis with GLP 1 analog therapy, analysing the speed and magnitude of weight loss and circumferential changes. Introduction: Cryolipolysis is a non invasive technique for reducing localized fat by selectively cooling adipocytes and inducing apoptosis¹. In parallel, pharmacological weight loss achieved with GLP 1 receptor agonists enhances satiety and produces significant reductions in body measurements². This case series compares the combined use of both methods with cryolipolysis alone, aiming to assess differences in the rate of weight and girth reduction. Materials / method: Four men aged 28–47 years with localized fat in the abdomen and flanks were included. Two underwent combined treatment with a GLP 1 agonist plus cryolipolysis, while the other two received only cryolipolysis. Each patient had a single session using two to four applicators. Follow up was conducted at 60 days. Outcomes were assessed with validated three dimensional photographic analysis software, allowing volumetric and linear measurements. Patients with contraindications to cold exposure were excluded. Results: After 60 days, the combined group showed a mean weight reduction of 15.9 kg (−14.7 %), whereas the cryolipolysis only group showed a mean reduction of 0.5 kg (−0.5 %). 3D analysis demonstrated abdominal reductions of up to 18.5 cm in the combined group, while the control group showed no relevant changes. The largest decreases were observed in the upper abdomen, umbilical line and lower abdomen. Volumetric loss was proportional to weight loss only in patients receiving GLP 1 therapy. Conclusion: The association of GLP 1 receptor agonists with cryolipolysis was linked to greater reductions in weight and body measurements compared with cryolipolysis alone. Three dimensional analysis contributed to the objective evaluation of volumetric changes. Despite these preliminary findings, the small sample size limits generalisation, and larger studies are needed to validate the results.