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Objectives: Increase the effectiveness of traumatic procedures through guided cell regeneration, improve the results of plastic surgery, thanks to the prevention of pathological scarring

Introduction: Currently,the field of aesthetic medicine offers a large number of effective rejuvenation techniques,both minimally invasive and surgical. However, in any case, all these methods are traumatic,and rejuvenation is inevitably realized through the wound process. Patients who enter the cosmetologist's office are considered healthy,which means they do not undergo an extended medical examination, which increases the risk zone for both the patient and his doctor. And even if the protocol of the procedure or operation is followed,the wound process may be complicated,which will lead to new problems.

Materials / method: This report briefly presents the main links in the pathogenesis of the wound process, its key participants, as well as available effective means to enhance regeneration and prevent adverse events and complications as a result of any traumatic effects on the skin. The available effective means for use in different phases of the wound process are considered with the analysis of specific clinical cases.

Results: Due to the correct diagnosis of the phase of the wound process and the timely start of the use of regenerants, the rehabilitation of patients is faster, and the aesthetic result from rejuvenating procedures and operations is more pronounced than with the use of "classic" post-procedure products.

Conclusion: The role of regenerative medicine cannot be overestimated, and the potentials inherent in the human body by nature itself are limitless and poorly understood.

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Objectives: This presentation serves to present our study investigating local alterations in hypertrophic scars. Attendees shall understand the differences between pathologic and non-pathologic scars as well as get insight into currently known scientific pathways of scar pathology.

Introduction: One of the long-term complications after every surgical procedure is the occurrence of hypertrophic scars. Depending on the available literature, they form in 30 to 70% of cases. Especially after elective aesthetic procedures these unwanted and disturbing scars present a major psychological and physical burden. Treatment modalities lack evidence not last because of the lack of standardized scar models.

Materials / method: Twenty-two standardized burn and 22 full-thickness skin wounds were placed on the backs of 6 Duroc pigs, whereas half of both had a prolonged inflammation with resiquimod induced. A modified Vancouver Scar Scale, hyperspectral photography and qPCR, and histology from biopsies were performed at defined time points to examine the different processes in the resulting wounds and scars.

Results: Native burn wounds as well as resiquimod-induced full-thickness and burn wounds resulted in more hypertrophic scars than full-thickness wounds. These three wound types also showed relative hypoxia compared with uninduced full-thickness wounds in hyperspectral imaging and increased genetic expression of hypoxia marker HIF1a. The highest number of inflammatory cells was detected in resiquimod-induced full-thickness wounds with histologic features of hypertrophic scars in burn and resiquimod-induced wounds.

Conclusion: According to our experiments, the use of resiquimod is suitable for provoking an earlier-occurring hypertrophic scar. The results suggest that hypoxia is the driving factor in promoting inflammation and thus the appearance of hypertrophic scars. This model allows for the generation of solid hypertrophic scars that can be used to further investigate and define working points in scar treatment, one of which should be the early oxygenation of wounds.

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Objectives: *area of tension or nodyschromia: erythema
*hypo or hyperpigmentation functionality *flexibility
*pruritus treatment expectations tissue mechanical stability individualized

Introduction: Pathological scars are caused by burns & traumas in 70% “it affects the quality of life” causing disregulation of the healing phases. “there is no gold standard and therapeutic guides” it is important to determine ethnicity & phototype type & evolution time of the scar anatomical location.

Materials / method: *multidisciplinary treatment ipl laser drug delivery silicone patches cryotherapy surgery radiot
*contracture symptoms
*neuropathic pain

Results: scar clearing in least time period

Conclusion: Combining treatments, lights and drugs, leads to the efficient treatment of scars

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