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Objectives: 1) To evaluate the effectiveness of a patented biomimetic peptide formulation, GFC and PRP in the treatment of Androgenetic Alopecia.

2) To compare the results of each of the three interventions at uniformly spaced time intervals

Introduction: Androgenetic alopecia (AGA) is the most common form of alopecia, affecting about 50% of the world's population. Topical Minoxidil solution, Platelet Rich Plasma (PRP) and Growth Factor Concentrate (GFC) are among the most common interventions in treating AGA. Although numerous treatment modalities exist, there is no apparent 'cure' for AGA. This study attempts to evaluate and compare the efficacy of PRP, GFC and a biomimetic peptide formulation developed for the treatment of alopecia.

Materials / method: A prospective, comparative, single-blind study was carried out with 3 groups of 25 patients each. Administration of the novel formulation through the micro-needling technique, GFC and PRP was done on the scalp in groups A, B and C respectively. Hair pull test, video-microscopic assessment, Global Photographic assessment was done and patients’ subjective assessment was done through a questionnaire at the end of the study. Results were evaluated after 6 months and follow-up was done for 1 year.

Results: The hair pull test was negative in 100% of the patients in group A, 72% in group B, and 52% in group C at 6 months. The results were better maintained in group A as compared to groups B and C over the next 1 year. The video-microscopic evaluation showed that the hair density, terminal hair density, vellus hair density and shaft diameter were significantly better in group A than in group B and C (P< .005). The mean value of Global Photographic Assessment at the baseline was 5 for all the groups, but increased to 8 at 6 months and was maintained at 7.5 at the end of 1 year.

Conclusion: The patented novel formulation of biomimetic peptides showed significant effectiveness in the treatment of alopecia as compared to PRP and GFC.

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