Objectives: The aim of this study to compare the results of injections of platelet-rich plasma (PRP) and platelet-rich plasma (PRP) in combination with stromal vascular fraction (SVF), which is rich in adipose-derived stromal cells (with a potential in modulating hair growth cycle) in the upper scalp for the treatment of AGA.

Introduction: Androgenetic alopecia (AGA) or male pattern baldness is characterized by reduction of the hair follicles gradually causing conversion of terminal hairs into vellus hair, leading to progressive reduction of the density of hair on the scalp.

Materials / method: In this study, 220 adult patients presenting with male pattern baldness were included. Patients were divided into two groups. Group 1 containing 110 patients received plain Platelet-Rich-Plasma (prp) treatment, while the second group was treated with PRP in combination with exosomes. Over the course of the study, a total of 6 sessions were conducted, with each session spaced 4 weeks apart. The results were assessed at the baseline, after 4thsession, and 1 month after 6th session. Pre and post trichoscopy images were taken.
The assessment of outcomes included both re-injection and changes in ha

Results: Hair density was significantly increased after 6 weeks and 12 weeks post injection were seen with platelet-rich plasma (PRP) in combination with exosomes In hair-to-hair matching analyses, new hair grew from active follicles. Furthermore, nonfunctioning hair follicles filled with hyperkeratotic plugs, up to today assumed incapable of forming new hair, proved to grow new hair. No side effects were noted after treatment.

Conclusion: Intra dermal administration of platelet-rich plasma in combination with exosomes showed significant increase in hair density, improves hair regrowth within 6 to 12 weeks. Overall, exosomes hold promise in influencing the hair growth cycle and may serve as a potential therapy in AGA.

利益冲突声明

您有否接受任何资金来支持研究这个主题？
否

您是否接受过关于这项研究的任何酬金或其他报酬？
否

你是否和任何与您的研究所涉及的药物，材料或工具有密切联系的实体存在财务关系？
否

你是否拥有或者您已经为您此研究中的工具，药物或材料申请任何专利？
否

这项工作没有任何直接或间接的资金支持。由作者自己承担责任。