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Objectives: 1: Understand the role of senescent cells in skin ageing
2: Discuss strategies and challenges for addressing senescent cell impact in skin ageing

Introduction: As cells get older, they accumulate damage which, once it disrupts normal cell function, can lead to cellular senescence. In this state, cells are unable to divide, become larger and release many secretory factors, such as inflammatory cytokines, which can damage surrounding cells and tissue. There have now been a plethora of studies investigating the detrimental effects of senescent cells, although the ways in which such negative impacts can be ameliorated is less well known.

Materials / method: We reviewed the literature to determine what is currently known about senescent cells in skin and approaches for addressing the consequence of their presence. In addition, we discuss our research in which we have screened compounds for their ability to target senescent skin cells in vitro with a view to provide anti-ageing benefits in skin; this approach offers a topical route for testing anti-ageing approaches towards senescent cells in human tissues.

Results: Senomorphics offer one route to address the negative effects of senescent cells in skin by suppressing their secretion of detrimental factors that damage surrounding tissue. There are several known compounds that can clear senescent cells (known as senolytic compounds) although their use in clinic is still under evaluation. Early results from our research highlight the impact of laboratory conditions (cells and models) on the relevance of in vitro senescent cells to in vivo cells, and further work to understand the importance of this for clinical trials is required.

Conclusion: Senescent cells accumulate with age in human skin but drivers of their formation and the exact characteristics of these cells is relatively unknown. Routes to address the presence and impact of these cells, such as senolytic and senomorphic compounds, have shown promise in in vitro tests but further studies are now required to determine how effective such compounds are on human skin in vivo.

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请注明名称（个人，公司，学会等等）: UNILEVER

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请注明名称（个人，公司，学会等等）: UNILEVER

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请注明名称（个人，公司，学会等等）: UNILEVER

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请注明日期: PATENT PENDING
和审阅情况: UNILEVER 2020, 2021

这项工作的完成感谢以下机构的支持： UNILEVER

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Objectives: Upfront discussion on my personalized approach to the cosmetic consult and the combination procedures that I use to achieve superior results.

Introduction: COMBINATION PROCEDURES—

In my boutique cosmetic private practice about 12 miles/20 km from New York City – – combination procedures very much in demand. Most common combinations are Botox and filler,

Lase MD and Chemical peels, VI peels, cosmeceuticals and acne treatments, Kybella and Excel V, Keralase hair growth laser, Lambdapil shampoo and spray, and Nutrafol , Fraxel and IntraCel, Zaffiro and IntraGen, Emsculpt Neo and LipoCel, laser and sclerotherapy, Sculptra and IntraGen.

Materials / method: COSMETIC CONSULT—

*I have each patient hold the mirror up and tell me what they are concerned about as they age.

*I make a full face assessment to create a balanced beautiful result


*I ask them what their primary/secondary and tertiary

goals are that led them to my chair.

*I interpret my patients emotional experiences of facial/body aging into personalized cosmetic outcomes.

*In our practice, I communicate with passion what the benefits of each aesthetic treatment we offer our patients is rather than selling the treatment.

Results: I will show before and after pictures of all of these different combination procedures/ technologies, discuss best practices and how I get my results.

Conclusion: Each patient's face/body is unique and beautiful. As cosmetic dermatologists/ physicians, we need to interpret my patient's emotional experiences of facial/body aging into personalized cosmetic outcomes.

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